Nicole Boucheron/Division of Immunobiology
Background
Upon infection, naive CD4+ T cells get activated mainly in lymphatic organs, where they either remain to support humoral immunity and antibody production as T follicular helper cells (Tfh), or differentiate into functionally distinct helper subsets that migrate to the site of infection where they acquire additional specific effector functions. These specific effector functions will activate other specialized immune cells to optimally fight the infection. In addition, in organs, T helper cells can develop into tissue resident memory cells and rapidly orchestrate highly effective and optimized immune responses to recurrent infections. However, a dysregulation in these processes can lead to autoimmunity or allergies.
Main Research Interests
My main research interests are therefore the molecular control of T helper cell activation and differentiation, as well as the role of T helper subsets during immune responses and disease.
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