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Institute of Immunology
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Publications of the Institute of Immunology

Recent publications

Staniek J, Kalina T, Andrieux G, Boerries M, Janowska I, Fuentes M, Díez P, Bakardjieva M, Stancikova J, Raabe J, Neumann J, Schwenk S, Arpesella L, Stuchly J, Benes V, García Valiente R, Fernández García J, Carsetti R, Piano Mortari E, Catala A, de la Calle O, Sogkas G, Neven B, Rieux-Laucat F, Magerus A, Neth O, Olbrich P, Voll RE, Alsina L, Allende LM, Gonzalez-Granado LI, Böhler C, Thiel J, Venhoff N, Lorenzetti R, Warnatz K, Unger S, Seidl M, Mielenz D, Schneider P, Ehl S, Rensing-Ehl A, Smulski CR, Rizzi M. Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells. Sci Immunol. 2024 Jan 12;9(91):eadj5948. doi: 10.1126/sciimmunol.adj5948. Epub 2024 Jan 12. PMID: 38215192.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38215192/

Meyer M, Parpoulas C, Barthélémy T, Becker JP, Charoentong P, Lyu Y, Börsig S, Bulbuc N, Tessmer C, Weinacht L, Ibberson D, Schmidt P, Pipkorn R, Eichmüller SB, Steinberger P, Lindner K, Poschke I, Platten M, Fröhling S, Riemer AB, Hassel JC, Roberti MP, Jäger D, Zörnig I, Momburg F. MediMer: a versatile do-it-yourself peptide-receptive MHC class I multimer platform for tumor neoantigen-specific T cell detection. Front Immunol. 2024 Jan 4;14:1294565. doi: 10.3389/fimmu.2023.1294565. PMID: 38239352; PMCID: PMC10794645.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38239352/

Michalsen A, Goldenstein K, Kardos P, Klimek L, Palm J, Parganlija D, Stöckl J. The impact of cineole treatment timing on common cold duration and symptoms: Non-randomized exploratory clinical trial. PLoS One. 2024 Jan 18;19(1):e0296482. doi: 10.1371/journal.pone.0296482. PMID: 38236839; PMCID: PMC10795983.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38236839/

Sharma S, Whitehead T, Kotowski M, Ng EZQ, Clarke J, Leitner J, Chen YL, Santos AM, Steinberger P, Davis SJ. A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cells. Life Sci Alliance. 2023 Dec 7;7(3):e202302359. doi: 10.26508/lsa.202302359. PMID: 38073578; PMCID: PMC10703992.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38073578/

Izadi S, Gumpelmair S, Coelho P, Duarte HO, Gomes J, Leitner J, Kunnummel V, Mach L, Reis CA, Steinberger P, Castilho A. Plant-derived Durvalumab variants show efficient PD-1/PD-L1 blockade and therapeutically favourable FcR binding. Plant Biotechnol J. 2023 Dec 4. doi: 10.1111/pbi.14260. Epub ahead of print. PMID: 38050338.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38050338/

Sehgal ANA, Tauber PA, Stieger RB, Kratzer B, Pickl WF. The T-Cell Growth Factor Interleukin-2, Which Is Occasionally Targeted by Autoantibodies, Qualifies as Drug for the Treatment of Allergy, Autoimmunity, and Cancer: Collegium Internationale Allergologicum (CIA) Update 2024. Int Arch Allergy Immunol. 2023 Dec 12:1-15. doi: 10.1159/000533677. Epub ahead of print. PMID: 38086339.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38086339/

Funk MA, Leitner J, Gerner MC, Hammerler JM, Salzer B, Lehner M, Battin C, Gumpelmair S, Stiasny K, Grabmeier-Pfistershammer K, Steinberger P. Interrogating ligand-receptor interactions using highly sensitive cellular biosensors. Nat Commun. 2023 Nov 28;14(1):7804. doi: 10.1038/s41467-023-43589-1. PMID: 38016944; PMCID: PMC10684770.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38016944/

Sandner L, Alteneder M, Rica R, Woller B, Sala E, Frey T, Tosevska A, Zhu C, Madern M, Khan M, Hoffmann P, Schebesta A, Taniuchi I, Bonelli M, Schmetterer K, Iannacone M, Kuka M, Ellmeier W, Sakaguchi S, Herbst R, Boucheron N. The guanine nucleotide exchange factor Rin-like controls Tfh cell differentiation via CD28 signaling. J Exp Med. 2023 Nov 6;220(11):e20221466. doi: 10.1084/jem.20221466. Epub 2023 Sep 13. PMID: 37703004; PMCID: PMC10499045.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37703004/

Prickler L, Baranyi U, Mengrelis K, Weijler AM, Kainz V, Kratzer B, Steiner R, Mucha J, Rudoph E, Pilat N, Bohle B, Strobl H, Pickl WF, Valenta R, Linhart B, Wekerle T. Adoptive transfer of allergen-expressing B cells prevents IgE-mediated allergy. Front Immunol. 2023 Nov 23;14:1286638. doi: 10.3389/fimmu.2023.1286638. PMID: 38077381; PMCID: PMC10703460.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38077381/

Aigner-Radakovics K, De Sousa Linhares A, Salzer B, Lehner M, Izadi S, Castilho A, Pickl WF, Leitner J, Steinberger P. The ligand-dependent suppression of TCR signaling by the immune checkpoint receptor LAG3 depends on the cytoplasmic RRFSALE motif. Sci Signal. 2023 Oct 3;16(805):eadg2610. doi: 10.1126/scisignal.adg2610. Epub 2023 Oct 3. PMID: 37788323.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37788323/

Korzhenevich J, Janowska I, van der Burg M, Rizzi M. Human and mouse early B cell development: So similar but so different. Immunol Lett. 2023 Sep;261:1-12. doi: 10.1016/j.imlet.2023.07.004. Epub 2023 Jul 11. PMID: 37442242.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37442242/

Novak W, Berner J, Svaton M, Jimenez-Heredia R, Segarra-Roca A, Frohne A, Guiliani S, Rouhani D, Eder SK, Rottal A, Trapin D, Scheuchenstuhl A, Pickl WF, Simonitsch-Klupp I, Kager L, Boztug K. Evans syndrome caused by a deleterious mutation affecting the adaptor protein SASH3. Br J Haematol. 2023 Aug 30. doi: 10.1111/bjh.19061. Epub ahead of print. PMID: 37646304.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37646304/

Kuncewicz K, Bojko M, Battin C, Karczyńska A, Sieradzan A, Sikorska E, Węgrzyn K, Wojciechowicz K, Wardowska A, Steinberger P, Rodziewicz-Motowidło S, Spodzieja M. BTLA-derived peptides as inhibitors of BTLA/HVEM complex formation - design, synthesis and biological evaluation. Biomed Pharmacother. 2023 Sep;165:115161. doi: 10.1016/j.biopha.2023.115161. Epub 2023 Jul 19. PMID: 37473684.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37473684/

Kaiser FMP, Janowska I, Menafra R, de Gier M, Korzhenevich J, Pico-Knijnenburg I, Khatri I, Schulz AS, Kuijpers TW, Lankester AC, Konstantinidis L, Erlacher M, Kloet SL, van Schouwenburg PA, Rizzi M, van der Burg M. IL-7 receptor signaling drives human B-cell progenitor differentiation and expansion. Blood. 2023 Jun 27:blood.2023019721. doi: 10.1182/blood.2023019721. Epub ahead of print. PMID: 37369082.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37369082/

Battin C, De Sousa Linhares A, Leitner J, Grossmann A, Lupinek D, Izadi S, Castilho A, Waidhofer-Söllner P, Grabmeier-Pfistershammer K, Stritzker J, Steinberger P. Engineered soluble, trimerized 4-1BBL variants as potent immunomodulatory agents. Cancer Immunol Immunother. 2023 Jun 13. doi: 10.1007/s00262-023-03474-8. Epub ahead of print. PMID: 37310433.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37310433/

Block J, Rashkova C, Castanon I, Zoghi S, Platon J, Ardy RC, Fujiwara M, Chaves B, Schoppmeyer R, van der Made CI, Jimenez Heredia R, Harms FL, Alavi S, Alsina L, Sanchez Moreno P, Ávila Polo R, Cabrera-Pérez R, Kostel Bal S, Pfajfer L, Ransmayr B, Mautner AK, Kondo R, Tinnacher A, Caldera M, Schuster M, Domínguez Conde C, Platzer R, Salzer E, Boyer T, Brunner HG, Nooitgedagt-Frons JE, Iglesias E, Deyà-Martinez A, Camacho-Lovillo M, Menche J, Bock C, Huppa JB, Pickl WF, Distel M, Yoder JA, Traver D, Engelhardt KR, Linden T, Kager L, Hannich JT, Hoischen A, Hambleton S, Illsinger S, Da Costa L, Kutsche K, Chavoshzadeh Z, van Buul JD, Antón J, Calzada-Hernández J, Neth O, Viaud J, Nishikimi A, Dupré L, Boztug K. Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency. N Engl J Med. 2023 Jun 21. doi: 10.1056/NEJMoa2210054. Epub ahead of print. PMID: 37342957.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37342957/

Ettel P, Sehgal ANA, Harrison N, Pickl WF, Grabmeier-Pfistershammer K. Glycopeptide Antibiotics Impair Neutrophil Effector Functions. Int Arch Allergy Immunol. 2023 Jun 15:1-17. doi: 10.1159/000530865. Epub ahead of print. PMID: 37321197.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37321197/

Kratzer B, Grabmeier-Pfistershammer K, Trapin D, Körmöczi U, Rottal A, Feichter M, Waidhofer-Söllner P, Smogavec M, Laccone F, Hauser M, Winkler S, Pickl WF, Lechner AM. Mycobacterium avium Complex Infections: Detailed Phenotypic and Functional Immunological Work-Up Is Required despite Genetic Analyses. Int Arch Allergy Immunol. 2023 Jun 6:1-18. doi: 10.1159/000530844. Epub ahead of print. PMID: 37279717.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37279717/

Cyr MG, Wilson HD, Spierling AL, Chang J, Peng H, Steinberger P, Rader C. Concerted Antibody and Antigen Discovery by Differential Whole-cell Phage Display Selections and Multi-omic Target Deconvolution. J Mol Biol. 2023 May 15;435(10):168085. doi: 10.1016/j.jmb.2023.168085. Epub 2023 Apr 3. PMID: 37019174; PMCID: PMC10148915.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37019174/

Eder M, Pimenov L, Böhmig GA, Kornek B, Göschl L, Bond G, Vossen MG, Pickl WF, Breuer M, Görzer I, Kozakowski N, Laferl H, Winkler S. Lessons for the Clinical Nephrologist: Nephrotic syndrome associated with refractory Giardia duodenalis infection in a patient with acquired B cell depletion. J Nephrol. 2023 May;36(4):1197-1201. doi: 10.1007/s40620-023-01601-3. Epub 2023 Mar 17. PMID: 36930433; PMCID: PMC10021039.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36930433/

Cox EM, El-Behi M, Ries S, Vogt JF, Kohlhaas V, Michna T, Manfroi B, Al-Maarri M, Wanke F, Tirosh B, Pondarre C, Lezeau H, Yogev N, Mittenzwei R, Descatoire M, Weller S, Weill JC, Reynaud CA, Boudinot P, Jouneau L, Tenzer S, Distler U, Rensing-Ehl A, König C, Staniek J, Rizzi M, Magérus A, Rieux-Laucat F, Wunderlich FT, Hövelmeyer N, Fillatreau S. AKT activity orchestrates marginal zone B cell development in mice and humans. Cell Rep. 2023 Apr 14;42(4):112378. doi: 10.1016/j.celrep.2023.112378. Epub ahead of print. PMID: 37060566.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37060566/

Tauber PA, Kratzer B, Schatzlmaier P, Smole U, Köhler C, Rausch L, Kranich J, Trapin D, Neunkirchner A, Zabel M, Jutz S, Steinberger P, Gadermaier G, Brocker T, Stockinger H, Derdak S, Pickl WF. The small molecule inhibitor BX-795 uncouples IL-2 production from inhibition of Th2 inflammation and induces CD4+ T cells resembling iTreg. Front Immunol. 2023 Apr 6;14:1094694. doi: 10.3389/fimmu.2023.1094694. PMID: 37090735; PMCID: PMC10117943.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37090735/

Cousin VN, Perez GF, Payne KJ, Voll RE, Rizzi M, Mueller CG, Warnatz K. Lymphoid stromal cells - potential implications for the pathogenesis of CVID. Front Immunol. 2023 Feb 17;14:1122905. doi: 10.3389/fimmu.2023.1122905. PMID: 36875120; PMCID: PMC9982092.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36875120/

Metz M, Gualdoni GA, Winkler HM, Warenits AM, Stöckl J, Burgmann H, Winkler S, Oesterreicher ZA. MxA for differentiating viral and bacterial infections in adults: a prospective, exploratory study. Infection. 2023 Feb 3:1–9. doi: 10.1007/s15010-023-01986-0. Epub ahead of print. PMID: 36737561; PMCID: PMC9897883.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36737561

Worel N, Grabmeier-Pfistershammer K, Kratzer B, Schlager M, Tanzmann A, Rottal A, Körmöczi U, Porpaczy E, Staber PB, Skrabs C, Herkner H, Gudipati V, Huppa JB, Salzer B, Lehner M, Saxenhuber N, Friedberg E, Wohlfarth P, Hopfinger G, Rabitsch W, Simonitsch-Klupp I, Jäger U, Pickl WF. The frequency of differentiated CD3+CD27-CD28- T cells predicts response to CART cell therapy in diffuse large B-cell lymphoma. Front Immunol. 2023 Jan 9;13:1004703.
doi: 10.3389/fimmu.2022.1004703. PMID: 36700229; PMCID: PMC9868136.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36700229/

Frede N, Lorenzetti R, Hüppe JM, Janowska I, Troilo A, Schleyer MT, Venhoff AC, Voll RE, Thiel J, Venhoff N, Rizzi M. JAK inhibitors differentially modulate B cell activation, maturation and function: A comparative analysis of five JAK inhibitors in an in-vitro B cell differentiation model and in patients with rheumatoid arthritis. Front Immunol. 2023 Jan 26;14:1087986. doi: 10.3389/fimmu.2023.1087986. PMID: 36776828; PMCID: PMC9908612.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36776828/

Klasinc R, Battin C, Paster W, Reiter M, Schatzlmaier P, Rhein P, Spittler A, Steinberger P, Stockinger H. TLR4/CD14/MD2 Revealed as the Limited Toll-like Receptor Complex for Chlamydia trachomatis-Induced NF-κB Signaling. Microorganisms. 2022 Dec 15;10(12):2489. doi: 10.3390/microorganisms10122489. PMID: 36557742; PMCID: PMC9783372.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36557742/