Publikationen des Instituts für Immunologie
Aktuelle Publikationen
Schmidt FM, Rizzi M. Human B-lymphopoiesis: Clinical challenges in B cell reconstitution and advances in in vitro modeling. Immunol Lett. 2025 Nov 3:107106. doi: 10.1016/j.imlet.2025.107106. Epub ahead of print. PMID: 41192681.
Abstract: https://pubmed.ncbi.nlm.nih.gov/41192681/
Bojko M, Leitner J, Steinberger P. Evaluation of Immune Checkpoint Inhibitors in a Jurkat-Based Transcriptional Reporter System: A Cell-Based Reporter Platform for Evaluation of Immune Checkpoint Inhibitors. Methods Mol Biol. 2026;2959:73-83. doi: 10.1007/978-1-0716-4734-9_5. PMID: 41028259.
Abstract: https://pubmed.ncbi.nlm.nih.gov/41028259/
Kratzer B, Stieger RB, Durmus S, Trapin D, Gattinger P, Ettel P, Sehgal ANA, Borochova K, Dorofeeva Y, Tulaeva I, Grabmeier-Pfistershammer K, Tauber PA, Gerdov M, Perkmann T, Fae I, Wenda S, Kundi M, Wrighton S, Fischer GF, Valenta R, Pickl WF. Severe COVID-19 induces prolonged elevation of the acute-phase protein pentraxin 3. Front Immunol. 2025 Oct 1;16:1672485. doi: 10.3389/fimmu.2025.1672485. PMID: 41103408; PMCID: PMC12520919.
Abstract: https://pubmed.ncbi.nlm.nih.gov/41103408/
Ciura P, Gumpelmair S, Sikorska E, Rodziewicz-Motowidło S, Steinberger P, Spodzieja M, Sieradzan AK. HVEM-derived peptides as inhibitors of HVEM/LIGHT complex formation. Bioorg Chem. 2025 Oct 31;166:109183. doi: 10.1016/j.bioorg.2025.109183. Epub ahead of print. PMID: 41197453.
Abstract: https://pubmed.ncbi.nlm.nih.gov/41197453/
Rica R, Waldherr M, Miyakoda E, Kutschat AP, Schülein M, Zhang J, Orbegozo-Medina RA, Sandner L, Stolz V, Waltenberger D, Krausgruber T, Bock C, Boucheron N, Seruggia D, Ellmeier W, Sakaguchi S. HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection. J Exp Med. 2025 Aug 4;222(8):e20240829. doi: 10.1084/jem.20240829. Epub 2025 Jun 4. PMID: 40464916; PMCID: PMC12135962.
Abstract: https://pubmed.ncbi.nlm.nih.gov/40464916/
Kratzer B, Gattinger P, Tauber PA, Schaar M, Sehgal ANA, Kraus A, Trapin D, Valenta R, Pickl WF. Moloney Murine Leukemia Virus-like Nanoparticles Pseudo-Typed with SARS-CoV-2 RBD for Vaccination Against COVID-19. Int J Mol Sci. 2025 Jul 4;26(13):6462. doi: 10.3390/ijms26136462. PMID: 40650237; PMCID: PMC12250557.
Abstract: https://pubmed.ncbi.nlm.nih.gov/40650237/
Gil-Cantero S, Künig S, Aigner-Radakovics K, Steinberger P, Boccaccini AR, Stöckl J. Recognition of degradation-derived products from biomedical scaffolds by Toll-like receptors. Biomaterials. 2026 Jan;324:123442. doi: 10.1016/j.biomaterials.2025.123442. Epub 2025 May 30. PMID: 40527085.
Abstract: https://pubmed.ncbi.nlm.nih.gov/40527085/
Protić-Rosić I, Sehgal ANA, Wrighton S, Heller B, Pickl WF. Chimeric Autoantibody Receptor- and/or Peptide-MHC-Based CAR Therapies for Targeted Elimination of Antigen-Specific B or T Cells in Hypersensitivity Disorders Such as Allergies and Autoimmune Diseases. Cells. 2025 May 21;14(10):753. doi: 10.3390/cells14100753. PMID: 40422256; PMCID: PMC12110022.
Abstract: https://pubmed.ncbi.nlm.nih.gov/40422256/
Brinkmann M, Traby L, Kussmann M, Weiss-Tessbach M, Buchtele N, Staudinger T, Gaidoschik E, Perkmann T, Haslacher H, Ratzinger F, Pickl WF, El-Gedawi K, Feichter M, Gelpi E, Höftberger R, Quehenberger P, Marculescu R, Mrak D, Kastrati K, Lechner-Radner H, Sieghart D, Aletaha D, Winkler S, Bonelli M, Göschl L. Autoantibody development is associated with clinical severity of COVID-19: A cohort study. Clin Immunol. 2025 May;274:110471. doi: 10.1016/j.clim.2025.110471. Epub 2025 Mar 3. PMID: 40044018.
Abstract: https://pubmed.ncbi.nlm.nih.gov/40044018/
Arp AB, Abel Gutierrez A, Ter Beest M, Franken GA, Warner H, Rodgers Furones A, Kenyon AN, Jäger F, Cabrera-Orefice A, Kläsener K, van Deventer S, Droesen L, Dunlock VME, Classens R, Staniek J, Borst J, Reth M, Brandt U, Gros P, Kuijpers TW, Heemskerk MHM, Rizzi M, Querol Cano L, van Spriel AB. CD70 recruitment to the immunological synapse is dependent on CD20 in B cells. Proc Natl Acad Sci U S A. 2025 Apr 22;122(16):e2414002122. doi: 10.1073/pnas.2414002122. Epub 2025 Apr 15. PMID: 40232798; PMCID: PMC12037035.
Abstract: https://pubmed.ncbi.nlm.nih.gov/40232798/
Gil-Cantero S, Puck A, Künig S, Pinnarò V, Waidhofer-Söllner P, Stöckl J. The Soluble Cytoplasmic Tail of CD45 (ct-CD45) Regulates Dendritic Cell Activation and Function via TLR4 Signaling. Int J Mol Sci. 2025 Apr 20;26(8):3888. doi: 10.3390/ijms26083888. PMID: 40332754; PMCID: PMC12027817.
Abstract: https://pubmed.ncbi.nlm.nih.gov/40332754/
Mühlgrabner V, Plach A, Holler J, Leitner J, Steinberger P, Dupré L, Göhring J, Huppa JB. Gauging antigen recognition by human primary T-cells featuring orthotopically exchanged TCRs of choice. Methods Cell Biol. 2025;193:127-154. doi: 10.1016/bs.mcb.2024.03.003. Epub 2024 Apr 15. PMID: 39919839.
Abstract: https://pubmed.ncbi.nlm.nih.gov/39919839/
Zrimšek M, Draganić K, Malzer A, Doblmayr V, Mišura K, de Freitas E Silva R, Matthews JD, Iannelli F, Wohlhaupter S, Pérez Malla CU, Fischer H, Schachner H, Schiefer AI, Sheibani-Tezerji R, Chiarle R, Turner SD, Ellmeier W, Seiser C, Egger G. HDAC1 acts as a tumor suppressor in ALK-positive anaplastic large cell lymphoma: implications for HDAC inhibitor therapy. Leukemia. 2025 Apr 2. doi: 10.1038/s41375-025-02584-9. Epub ahead of print. PMID: 40175628.
Abstract: https://pubmed.ncbi.nlm.nih.gov/40175628/
Voogd L, van den Broek RL, van Wolfswinkel M, Franken KLMC, Ruibal P, Jespers W, Leitner J, Steinberger P, van Westen GJP, Ottenhoff THM, Joosten SA. HLA-E/peptide complexes differentially interact with NKG2A/CD94 and T cell receptors. J Immunol. 2025 Apr 1;214(4):595-605. doi: 10.1093/jimmun/vkae068. PMID: 40085431; PMCID: PMC12041767.
Abstract: https://pubmed.ncbi.nlm.nih.gov/40085431/
Izadi S, Abrantes R, Gumpelmair S, Kunnummel V, Duarte HO, Steinberger P, Reis CA, Castilho A. An engineered PD1-Fc fusion produced in N. benthamiana plants efficiently blocks PD1/PDL1 interaction. Plant Cell Rep. 2025 Mar 22;44(4):80. doi: 10.1007/s00299-025-03475-0. PMID: 40119938; PMCID: PMC11929711.
Abstract: https://pubmed.ncbi.nlm.nih.gov/40119938/
Farhat A, Radhouani M, Deckert F, Zahalka S, Pimenov L, Fokina A, Hakobyan A, Oberndorfer F, Brösamlen J, Hladik A, Lakovits K, Meng F, Quattrone F, Boon L, Vesely C, Starkl P, Boucheron N, Menche J, van der Veeken J, Ellmeier W, Gorki AD, Campbell C, Gawish R, Knapp S. An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence. Sci Immunol. 2025 Mar 28;10(105):eadk5041. doi: 10.1126/sciimmunol.adk5041. Epub 2025 Mar 28. PMID: 40153488.
Abstract: https://pubmed.ncbi.nlm.nih.gov/40153488/
Wideman SK, Wali L, Kovtunyk V, Chou S, Gusel V, Telimaa H, Najmi C, Stoeva D, Stöckl J, Gualdoni GA, Gorki AD, Radivojev S. Nebulized 2-deoxylated glucose analogues inhibit respiratory viral infection in advanced in vitro airway models. Sci Rep. 2025 Mar 19;15(1):9515. doi: 10.1038/s41598-025-94476-2. PMID: 40108297; PMCID: PMC11923073.
Abstract: https://pubmed.ncbi.nlm.nih.gov/40108297/
Staniek J, Rizzi M. Signaling Activation and Modulation in Extrafollicular B Cell Responses. Immunol Rev. 2025 Mar;330(1):e70004. doi: 10.1111/imr.70004. PMID: 39917832; PMCID: PMC11803499.
Abstract: https://pubmed.ncbi.nlm.nih.gov/39917832/
Khan M, Alteneder M, Reiter W, Krausgruber T, Dobnikar L, Madern M, Waldherr M, Bock C, Hartl M, Ellmeier W, Henriksson J, Boucheron N. Single-cell and chromatin accessibility profiling reveals regulatory programs of pathogenic Th2 cells in allergic asthma. Nat Commun. 2025 Mar 15;16(1):2565. doi: 10.1038/s41467-025-57590-3. PMID: 40089475; PMCID: PMC11910648.
Abstract: https://pubmed.ncbi.nlm.nih.gov/40089475/
Zhu C, Boucheron N, Al-Rubaye O, Chung BK, Thorbjørnsen LW, Köcher T, Schuster M, Claudel T, Halilbasic E, Kunczer V, Muscate F, Cavanagh LL, Waltenberger D, Lercher A, Ohradanova-Repic A, Schatzlmaier P, Stojakovic T, Scharnagl H, Bergthaler A, Stockinger H, Huber S, Bock C, Kenner L, Karlsen TH, Ellmeier W, Trauner M. 24-Nor-ursodeoxycholic acid improves intestinal inflammation by targeting TH17 pathogenicity and transdifferentiation. Gut. 2025 Mar 7:gutjnl-2024-333297. doi: 10.1136/gutjnl-2024-333297. Epub ahead of print. PMID: 40032499.
Abstract: https://pubmed.ncbi.nlm.nih.gov/40032499/
Diehl R, Hübner S, Lehr S, Rizzi M, Eyerich K, Nyström A. Skin Deep and Beyond: Unravelling B Cell Extracellular Matrix Interactions in Cutaneous Immunity and Disease. Exp Dermatol. 2025 Mar;34(3):e70068. doi: 10.1111/exd.70068. PMID: 40051023; PMCID: PMC11885703.
Abstract: https://pubmed.ncbi.nlm.nih.gov/40051023/
Tajti G, Gebetsberger L, Pamlitschka G, Aigner-Radakovics K, Leitner J, Steinberger P, Stockinger H, Ohradanova-Repic A. Cyclophilin-CD147 interaction enables SARS-CoV-2 infection of human monocytes and their activation via Toll-like receptors 7 and 8. Front Immunol. 2025 Feb 3;16:1460089. doi: 10.3389/fimmu.2025.1460089. PMID: 39963132; PMCID: PMC11830813.
Abstract: https://pubmed.ncbi.nlm.nih.gov/39963132/