2021

Publications 2021

Affandi AJ, Olesek K, Grabowska J, Nijen Twilhaar MK, Rodríguez E, Saris A, Zwart ES, Nossent EJ, Kalay H, de Kok M, Kazemier G, Stöckl J, van den Eertwegh AJM, de Gruijl TD, Garcia-Vallejo JJ, Storm G, van Kooyk Y, den Haan JMM. CD169 Defines Activated CD14 ⁺ Monocytes With Enhanced CD8 ⁺ T Cell Activation Capacity. Front Immunol 12:697840. doi: 10.3389/fimmu.2021.697840. eCollection 2021.
Abstract: www.ncbi.nlm.nih.gov/pubmed/34394090.

Agerer, B., M. Koblischke, V. Gudipati, L. F. Montano-Gutierrez, M. Smyth, A. Popa, J. W. Genger, L. Endler, D. M. Florian, V. Muhlgrabner, M. Graninger, S. W. Aberle, A. M. Husa, L. E. Shaw, A. Lercher, P. Gattinger, R. Torralba-Gombau, D. Trapin, T. Penz, D. Barreca, I. Fae, S. Wenda, M. Traugott, G. Walder, W. F. Pickl, V. Thiel, F. Allerberger, H. Stockinger, E. Puchhammer-Stockl, W. Weninger, G. Fischer, W. Hoepler, E. Pawelka, A. Zoufaly, R. Valenta, C. Bock, W. Paster, R. Geyeregger, M. Farlik, F. Halbritter, J. B. Huppa, J. H. Aberle and A. Bergthaler. SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8(+) T cell responses. Sci Immunol 6(57) doi: 10.1126/sciimmunol.abg6461 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/33664060.

Akinfenwa, O., H. J. Huang, B. Linhart, M. Focke-Tejkl, S. Vrtala, A. Poroshina, A. Nikonova, M. Khaitov, N. J. Campion, J. Eckl-Dorna, V. Niederberger-Leppin, B. Kratzer, P. A. Tauber, W. F. Pickl, M. Kundi, R. Campana and R. Valenta. Preventive Administration of Non-Allergenic Bet v 1 Peptides Reduces Allergic Sensitization to Major Birch Pollen Allergen, Bet v 1. Front Immunol 12: 744544 doi: 10.3389/fimmu.2021.744544 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/34795666.

Arranz-Nicolas, J., M. Martin-Salgado, I. Adan-Barrientos, R. Liebana, M. Del Carmen Moreno-Ortiz, J. Leitner, P. Steinberger, A. Avila-Flores and I. Merida. Diacylglycerol kinase alpha inhibition cooperates with PD-1-targeted therapies to restore the T cell activation program. Cancer Immunol Immunother 70(11): 3277-3289 doi: 10.1007/s00262-021-02924-5 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/33837851.

Dorofeeva, Y., Shilovskiy, I., Tulaeva, I., Focke-Tejkl, M., Flicker, S., Kudlay, D., Khaitov, M., Karsonova, A., Riabova, K., Karaulov, A., Khanferyan, R., Pickl, W. F., Wekerle, T. & Valenta, R. Past, present, and future of allergen immunotherapy vaccines. Allergy 76, 131-149, doi:10.1111/all.14300 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/32249442.

Gattinger, P., K. Borochova, Y. Dorofeeva, R. Henning, R. Kiss, B. Kratzer, B. Muhl, T. Perkmann, D. Trapin, M. Trella, P. Ettel, I. Tulaeva, W. F. Pickl and R. Valenta. Antibodies in serum of convalescent patients following mild COVID-19 do not always prevent virus-receptor binding. Allergy 76(3): 878-883 doi: 10.1111/all.14523 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/32734595.

Gattinger, P., K. Niespodziana, K. Stiasny, S. Sahanic, I. Tulaeva, K. Borochova, Y. Dorofeeva, T. Schlederer, T. Sonnweber, G. Hofer, R. Kiss, B. Kratzer, D. Trapin, P. A. Tauber, A. Rottal, U. Kormoczi, M. Feichter, M. Weber, M. Focke-Tejkl, J. Loffler-Ragg, B. Muhl, A. Kropfmuller, W. Keller, F. Stolz, R. Henning, I. Tancevski, E. Puchhammer-Stockl, W. F. Pickl and R. Valenta. Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes. Allergy doi: 10.1111/all.15066 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/34453317.

Gheerbrant, H., A. Guillien, R. Vernet, C. Lupinek, C. Pison, I. Pin, F. Demenais, R. Nadif, J. Bousquet, W. F. Pickl, R. Valenta, E. Bouzigon and V. Siroux. Associations between specific IgE sensitization to 26 respiratory allergen molecules and HLA class II alleles in the EGEA cohort. Allergy 76(8): 2575-2586 doi: 10.1111/all.14820 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/33742477.

Gülich, A. F., R. Rica, C. Tizian, C. Viczenczova, K. Khamina, T. Faux, D. Hainberger, T. Penz, R. Bosselut, C. Bock, A. Laiho, L. L. Elo, A. Bergthaler, W. Ellmeier and S. Sakaguchi. Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells. Front Immunol 12: 535039 doi: 10.3389/fimmu.2021.535039 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/33815354

Hamminger, P., L. Marchetti, T. Preglej, R. Platzer, C. Zhu, A. Kamnev, R. Rica, V. Stolz, L. Sandner, M. Alteneder, E. Kaba, D. Waltenberger, J. B. Huppa, M. Trauner, C. Bock, R. Lyck, J. Bauer, L. Dupre, C. Seiser, N. Boucheron, B. Engelhardt and W. Ellmeier. Histone deacetylase 1 controls CD4(+) T cell trafficking in autoinflammatory diseases. J Autoimmun 119: 102610 doi: 10.1016/j.jaut.2021.102610 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/33621930

Harrison, N., K. Grabmeier-Pfistershammer, A. Graf, D. Trapin, P. Tauber, J. H. Aberle, K. Stiasny, R. Schmidt, H. Greinix, W. Rabitsch, M. Ramharter, H. Burgmann, W. F. Pickl and C. Bahrs. Tick-Borne Encephalitis Specific Lymphocyte Response after Allogeneic Hematopoietic Stem Cell Transplantation Predicts Humoral Immunity after Vaccination. Vaccines (Basel) 9(8) doi: 10.3390/vaccines9080908 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/34452033

Julamanee, J., S. Terakura, K. Umemura, Y. Adachi, K. Miyao, S. Okuno, E. Takagi, T. Sakai, D. Koyama, T. Goto, R. Hanajiri, M. Hudecek, P. Steinberger, J. Leitner, T. Nishida, M. Murata and H. Kiyoi. Composite CD79A/CD40 co-stimulatory endodomain enhances CD19CAR-T cell proliferation and survival. Mol Ther 29(9): 2677-2690 doi: 10.1016/j.ymthe.2021.04.038 (2021).
Abstract:www.ncbi.nlm.nih.gov/pubmed/33940156.

Kratzer, B., D. Trapin, P. Ettel, U. Kormoczi, A. Rottal, F. Tuppy, M. Feichter, P. Gattinger, K. Borochova, Y. Dorofeeva, I. Tulaeva, M. Weber, K. Grabmeier-Pfistershammer, P. A. Tauber, M. Gerdov, B. Muhl, T. Perkmann, I. Fae, S. Wenda, H. Fuhrer, R. Henning, R. Valenta and W. F. Pickl. Immunological imprint of COVID-19 on human peripheral blood leukocyte populations. Allergy 76(3): 751-765 doi: 10.1111/all.14647 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/33128792.

Laurent, E., A. Sieber, B. Salzer, A. Wachernig, J. Seigner, M. Lehner, R. Geyeregger, B. Kratzer, U. Jager, R. Kunert, W. F. Pickl and M. W. Traxlmayr. Directed Evolution of Stabilized Monomeric CD19 for Monovalent CAR Interaction Studies and Monitoring of CAR-T Cell Patients. ACS Synth Biol 10(5): 1184-1198 doi: 10.1021/acssynbio.1c00010 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/33843201.

Leitner, J., C. Battin, K. Grabmeier-Pfistershammer and P. Steinberger. PD-1 blocking antibodies moonlighting as killers. Eur J Immunol 51(6): 1361-1364 doi: 10.1002/eji.202149276 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/33954999.

Leitner, J., K. Mahasongkram, P. Schatzlmaier, K. Pfisterer, V. Leksa, S. Pata, W. Kasinrerk, H. Stockinger and P. Steinberger. Differentiation and activation of human CD4 T cells is associated with a gradual loss of myelin and lymphocyte protein. Eur J Immunol 51(4): 848-863 doi: 10.1002/eji.202048603 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/33345332.

Mayer, K. A., U. Smole, C. Zhu, S. Derdak, A. A. Minervina, M. Salnikova, N. Witzeneder, A. Christamentl, N. Boucheron, P. Waidhofer-Sollner, M. Trauner, G. Hoermann, K. G. Schmetterer, I. Z. Mamedov, M. Bilban, W. Ellmeier, W. F. Pickl, G. A. Gualdoni and G. J. Zlabinger. The energy sensor AMPK orchestrates metabolic and translational adaptation in expanding T helper cells. FASEB J 35(4): e21217 doi: 10.1096/fj.202001763RR (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/33715236

Milburn, J. V., A. M. Hoog, S. Winkler, K. A. van Dongen, J. Leitner, M. Patzl, A. Saalmuller, K. de Luca, P. Steinberger, K. H. Mair and W. Gerner. Expression of CD9 on porcine lymphocytes and its relation to T cell differentiation and cytokine production. Dev Comp Immunol 121: 104080 doi: 10.1016/j.dci.2021.104080 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/33781781.

Muller, T. R., S. Jarosch, M. Hammel, J. Leube, S. Grassmann, B. Bernard, M. Effenberger, I. Andra, M. Z. Chaudhry, T. Kauferle, A. Malo, L. Cicin-Sain, P. Steinberger, T. Feuchtinger, U. Protzer, K. Schumann, M. Neuenhahn, K. Schober and D. H. Busch. Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy. Cell Rep Med 2(8): 100374 doi: 10.1016/j.xcrm.2021.100374 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/34467251.

Puck, A., S. Kunig, M. Modak, L. May, P. Fritz, C. Battin, K. Radakovics, P. Steinberger, B. M. Reipert, B. A. Crowe and J. Stockl. The soluble cytoplasmic tail of CD45 regulates T-cell activation via TLR4 signaling. Eur J Immunol doi: 10.1002/eji.202149227 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/34626426.

Redl, E., Sheibani-Tezerji, R., Cardona, C. J., Hamminger, P., Timelthaler, G., Hassler, M. R., Zrimsek, M., Lagger, S., Dillinger, T., Hofbauer, L., Draganic, K., Tiefenbacher, A., Kothmayer, M., Dietz, C. H., Ramsahoye, B. H., Kenner, L., Bock, C., Seiser, C., Ellmeier, W., Schweikert, G. & Egger, G. Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK-driven lymphomagenesis. Life Sci Alliance 4, doi:10.26508/lsa.202000794 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/3310759/

Reithofer, M., S. Rosskopf, J. Leitner, C. Battin, B. Bohle, P. Steinberger and B. Jahn-Schmid. 4-1BB costimulation promotes bystander activation of human CD8 T cells. Eur J Immunol 51(3): 721-733 doi: 10.1002/eji.202048762 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/33180337.

Santarsiero A, Convertini P, Vassallo A, Santoro V, Todisco S, Iacobazzi D, Fondufe-Mittendorf Y, Martelli G, de Oliveira MR, Montanaro R, Brancaleone V, Stöckl J, Infantino V. Phenolic Compounds of Red Wine Aglianico del Vulture Modulate the Functional Activity of Macrophages via Inhibition of NF-κB and the Citrate Pathway. Oxid Med Cell Longev:5533793. doi: 10.1155/2021/5533793.eCollection 2021.
Abstract: www.ncbi.nlm.nih.gov/pubmed/34122722

Tobias, J., P. Steinberger, M. Drinic and U. Wiedermann. Emerging targets for anticancer vaccination: PD-1. ESMO Open 6(5): 100278 doi: 10.1016/j.esmoop.2021.100278 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/34649221.

Untersmayr, E., E. Forster-Waldl, M. Bonelli, K. Boztug, P. M. Brunner, T. Eiwegger, K. Eller, L. Goschl, K. Grabmeier-Pfistershammer, W. Hotzenecker, G. Jordakieva, A. R. Moschen, B. Pfaller, W. Pickl, W. Reinisch, U. Wiedermann, L. Klimek, K. C. Bergmann, R. Brehler, W. Pfutzner, N. Novak, H. Merk, U. Rabe, W. Schlenter, J. Ring, W. Wehrmann, N. Mulleneisen, H. Wrede, T. Fuchs and E. Jensen-Jarolim. Immunologically relevant aspects of the new COVID-19 vaccines-an OGAI (Austrian Society for Allergology and Immunology) and AeDA (German Society for Applied Allergology) position paper. Allergo J Int: 1-14 doi: 10.1007/s40629-021-00178-2 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/34178577.

Zhu, C., N. Boucheron, A. C. Muller, P. Majek, T. Claudel, E. Halilbasic, H. Baazim, A. Lercher, C. Viczenczova, D. Hainberger, T. Preglej, L. Sandner, M. Alteneder, A. F. Gulich, M. Khan, P. Hamminger, J. Remetic, A. Ohradanova-Repic, P. Schatzlmaier, C. Donner, C. D. Fuchs, T. Stojakovic, H. Scharnagl, S. Sakaguchi, T. Weichhart, A. Bergthaler, H. Stockinger, W. Ellmeier and M. Trauner. 24-Norursodeoxycholic acid reshapes immunometabolism in CD8(+) T cells and alleviates hepatic inflammation. J Hepatol 75(5): 1164-1176 doi: 10.1016/j.jhep.2021.06.036 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/34242699.

Ziegler, L. S., Gerner, M. C., Schmidt, R. L. J., Trapin, D., Steinberger, P., Pickl, W. F., Sillaber, C., Egger, G., Schwarzinger, I. & Schmetterer, K. G. Attenuation of canonical NF-kappaB signaling maintains function and stability of human Treg. FEBS J 288, 640-662, doi:10.1111/febs.15361 (2021).
Abstract: www.ncbi.nlm.nih.gov/pubmed/32386462.