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2020

  1. Zentrum für Pathophysiologie, Infektiologie und Immunologie
  2. Unsere Abteilungen
  3. Institut für Immunologie
  4. Wissenschaft & Forschung/Forschungsabteilungen/Arbeitsgruppen
  5. Publikationen
  6. 2020

Publications 2020

Affandi, A. J., Grabowska, J., Olesek, K., Lopez Venegas, M., Barbaria, A., Rodriguez, E., Mulder, P. P. G., Pijffers, H. J., Ambrosini, M., Kalay, H., O'Toole, T., Zwart, E. S., Kazemier, G., Nazmi, K., Bikker, F. J., Stockl, J., van den Eertwegh, A. J. M., de Gruijl, T. D., Storm, G., van Kooyk, Y. & den Haan, J. M. M. Selective tumor antigen vaccine delivery to human CD169(+) antigen-presenting cells using ganglioside-liposomes. Proc Natl Acad Sci U S A 117, 27528-27539, doi:10.1073/pnas.2006186117 (2020).   Abstract: https://www.ncbi.nlm.nih.gov/pubmed/33067394.

Arranz-Nicolas, J., Martin-Salgado, M., Rodriguez-Rodriguez, C., Liebana, R., Moreno-Ortiz, M. C., Leitner, J., Steinberger, P., Avila-Flores, A. & Merida, I. Diacylglycerol kinase zeta limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes. J Immunother Cancer 8, doi:10.1136/jitc-2020-001521 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/33246984.

Berg, V., Modak, M., Brell, J., Puck, A., Kunig, S., Jutz, S., Steinberger, P., Zlabinger, G. J. & Stockl, J. Iron Deprivation in Human T Cells Induces Nonproliferating Accessory Helper Cells. Immunohorizons 4, 165-177, doi:10.4049/immunohorizons.2000003 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32284314.

De Sousa Linhares, A., Kellner, F., Jutz, S., Zlabinger, G. J., Gabius, H. J., Huppa, J. B., Leitner, J. & Steinberger, P. TIM-3 and CEACAM1 do not interact in cis and in trans. Eur J Immunol 50, 1126-1141, doi:10.1002/eji.201948400 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32222966.

Dufva, O., Koski, J., Maliniemi, P., Ianevski, A., Klievink, J., Leitner, J., Polonen, P., Hohtari, H., Saeed, K., Hannunen, T., Ellonen, P., Steinberger, P., Kankainen, M., Aittokallio, T., Keranen, M. A. I., Korhonen, M. & Mustjoki, S. Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity. Blood 135, 597-609, doi:10.1182/blood.2019002121 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31830245.

Emmerich, S., Hedwig, S., Arnoldi, B., Stockl, J., Haag, F., Hemm, R., Cinchetti, M., Mathias, S., Stadtmuller, B. & Aeschlimann, M. Ultrafast Charge-Transfer Exciton Dynamics in C60 Thin Films. J Phys Chem C Nanomater Interfaces 124, 23579-23587, doi:10.1021/acs.jpcc.0c08011 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/33193941.

Frohner, I. E., Mudrak, I., Schuchner, S., Anrather, D., Hartl, M., Sontag, J. M., Sontag, E., Wadzinski, B. E., Preglej, T., Ellmeier, W. & Ogris, E. PP2AC Phospho-Tyr(307) Antibodies Are Not Specific for this Modification but Are Sensitive to Other PP2AC Modifications Including Leu(309) Methylation. Cell Rep 30, 3171-3182 e3176, doi:10.1016/j.celrep.2020.02.035 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32130916.

Gattinger, P., Borochova, K., Dorofeeva, Y., Henning, R., Kiss, R., Kratzer, B., Muhl, B., Perkmann, T., Trapin, D., Trella, M., Ettel, P., Tulaeva, I., Pickl, W. F. & Valenta, R. Antibodies in serum of convalescent patients following mild COVID-19 do not always prevent virus-receptor binding. Allergy, doi:10.1111/all.14523 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32734595.

Gorris, A., Bustamante, G., Mayer, K. A., Kinaciyan, T. & Zlabinger, G. J. Cesarean section and risk of allergies in Ecuadorian children: A cross-sectional study. Immun Inflamm Dis 8, 763-773, doi:10.1002/iid3.368 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/33128350.

Goschl, L., Preglej, T., Boucheron, N., Saferding, V., Muller, L., Platzer, A., Hirahara, K., Shih, H. Y., Backlund, J., Matthias, P., Niederreiter, B., Hladik, A., Kugler, M., Gualdoni, G. A., Scheinecker, C., Knapp, S., Seiser, C., Holmdahl, R., Tillmann, K., Plasenzotti, R., Podesser, B., Aletaha, D., Smolen, J. S., Karonitsch, T., Steiner, G., Ellmeier, W. & Bonelli, M. Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis. J Autoimmun 108, 102379, doi:10.1016/j.jaut.2019.102379 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31883829.

Goschl, L., Winkler, S., Dmytrus, J., Heredia, R. J., Lagler, H., Ramharter, M., Scheinecker, C., Bonelli, M., Schmetterer, K., Pickl, W. F., Grabmeier-Pfistershammer, K., Hershfield, M. S., Boztug, K., Forster-Waldl, E. & Gualdoni, G. A. Unreported Missense Mutation in the Dimerization Domain of ADA2 Leads to ADA2 Deficiency Associated with Severe Oral Ulcers and Neutropenia in a Female Somalian Patient-Addendum to the Genotype-Phenotype Puzzle. J Clin Immunol 40, 223-226, doi:10.1007/s10875-019-00700-w (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31686313.

Grabmeier-Pfistershammer, K., Holleis, K., Rosskopf, S., Steinberger, P., Touzeau-Roemer, V., Poeppl, W. & Rieger, A. Low seroprotection rate for meningococcus serogroup C in the adult HIV-1-infected population in Austria. Wien Klin Wochenschr 132, 171-175, doi:10.1007/s00508-019-01561-4 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31650224.

Hainberger, D., Stolz, V., Zhu, C., Schuster, M., Muller, L., Hamminger, P., Rica, R., Waltenberger, D., Alteneder, M., Krausgruber, T., Hladik, A., Knapp, S., Bock, C., Trauner, M., Farrar, M. A. & Ellmeier, W. NCOR1 Orchestrates Transcriptional Landscapes and Effector Functions of CD4(+) T Cells. Front Immunol 11, 579, doi:10.3389/fimmu.2020.00579 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32318068.

Hamminger, P., Rica, R. & Ellmeier, W. Histone deacetylases as targets in autoimmune and autoinflammatory diseases. Adv Immunol 147, 1-59, doi:10.1016/bs.ai.2020.06.001 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32981634.

Jennifer, B., Berg, V., Modak, M., Puck, A., Seyerl-Jiresch, M., Kunig, S., Zlabinger, G. J., Steinberger, P., Chou, J., Geha, R. S., Ohler, L., Yachie, A., Choe, H., Kraller, M., Stockinger, H. & Stockl, J. Transferrin receptor 1 is a cellular receptor for human heme-albumin. Commun Biol 3, 621, doi:10.1038/s42003-020-01294-5 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/33110194.

Kohler, C., Smole, U., Kratzer, B., Trapin, D., Schmetterer, K. G. & Pickl, W. F. Allergen alters IL-2/alphaIL-2-based Treg expansion but not tolerance induction in an allergen-specific mouse model. Allergy 75, 1618-1629, doi:10.1111/all.14203 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31991489.

Kratzer, B., Hofer, S., Zabel, M. & Pickl, W. F. All the small things: How virus-like particles and liposomes modulate allergic immune responses. Eur J Immunol 50, 17-32, doi:10.1002/eji.201847810 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31799700.

Kratzer, B., Trapin, D., Ettel, P., Kormoczi, U., Rottal, A., Tuppy, F., Feichter, M., Gattinger, P., Borochova, K., Dorofeeva, Y., Tulaeva, I., Weber, M., Grabmeier-Pfistershammer, K., Tauber, P. A., Gerdov, M., Muhl, B., Perkmann, T., Fae, I., Wenda, S., Fuhrer, H., Henning, R., Valenta, R. & Pickl, W. F. Immunological imprint of COVID-19 on human peripheral blood leukocyte populations. Allergy, doi:10.1111/all.14647 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/33128792.

Kuncewicz, K., Battin, C., Sieradzan, A., Karczynska, A., Orlikowska, M., Wardowska, A., Pikula, M., Steinberger, P., Rodziewicz-Motowidlo, S. & Spodzieja, M. Fragments of gD Protein as Inhibitors of BTLA/HVEM Complex Formation-Design, Synthesis, and Cellular Studies. Int J Mol Sci 21, doi:10.3390/ijms21228876 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/33238640.

Lavelle, E. C., Carsetti, R., Pickl, W. F. & Wiedermann, U. Editorial: Challenges in Vaccinology. Front Immunol 11, 632537, doi:10.3389/fimmu.2020.632537 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/33391292.

Leitner, J., Mahasongkram, K., Schatzlmaier, P., Pfisterer, K., Leksa, V., Pata, S., Kasinrerk, W., Stockinger, H. & Steinberger, P. Differentiation and activation of human CD4 T-cells is associated with a gradual loss of myelin and lymphocyte protein. Eur J Immunol, doi:10.1002/eji.202048603 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/33345332.

Masel, E. K., Adamidis, F., Kitta, A., Gruebl, A., Unseld, M., Pavelka, P., Watzke, H. H., Zlabinger, G. & Praschinger, A. Using medical comics to explore challenging everyday topics in medicine: lessons learned from teaching medical humanities. Ann Palliat Med 9, 1841-1846, doi:10.21037/apm-20-261 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32527120.

Muller, T. R., Schuler, C., Hammel, M., Kohler, A., Jutz, S., Leitner, J., Schober, K., Busch, D. H. & Steinberger, P. A T-cell reporter platform for high-throughput and reliable investigation of TCR function and biology. Clin Transl Immunology 9, e1216, doi:10.1002/cti2.1216 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/33251011.

Podkowinski, D., Orlowski-Wimmer, E., Zlabinger, G., Pollreisz, A., Mursch-Edlmayr, A. S., Mariacher, S., Ring, M. & Bolz, M. Aqueous humour cytokine changes during a loading phase of intravitreal ranibizumab or dexamethasone implant in diabetic macular oedema. Acta Ophthalmol 98, e407-e415, doi:10.1111/aos.14297 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31736269.

Preglej, T., Hamminger, P., Luu, M., Bulat, T., Andersen, L., Goschl, L., Stolz, V., Rica, R., Sandner, L., Waltenberger, D., Tschismarov, R., Faux, T., Boenke, T., Laiho, A., Elo, L. L., Sakaguchi, S., Steiner, G., Decker, T., Bohle, B., Visekruna, A., Bock, C., Strobl, B., Seiser, C., Boucheron, N. & Ellmeier, W. Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation. JCI Insight 5, doi:10.1172/jci.insight.133393 (2020).Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32102981.

Reithofer, M., Rosskopf, S., Leitner, J., Battin, C., Bohle, B., Steinberger, P. & Jahn-Schmid, B. 4-1BB costimulation promotes bystander activation of human CD8 T cells. Eur J Immunol, doi:10.1002/eji.202048762 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/33180337.

Sakai, T., Terakura, S., Miyao, K., Okuno, S., Adachi, Y., Umemura, K., Julamanee, J., Watanabe, K., Hamana, H., Kishi, H., Leitner, J., Steinberger, P., Nishida, T., Murata, M. & Kiyoi, H. Artificial T Cell Adaptor Molecule-Transduced TCR-T Cells Demonstrated Improved Proliferation Only When Transduced in a Higher Intensity. Mol Ther Oncolytics 18, 613-622, doi:10.1016/j.omto.2020.08.014 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/33005728.

Schmid, N., Missel, A., Petkov, S., Stockl, J. B., Flenkenthaler, F., Arnold, G. J., Frohlich, T., Behr, R. & Mayerhofer, A. A translational cellular model for the study of peritubular cells of the testis. Reproduction 160, 259-268, doi:10.1530/REP-20-0100 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32449695.

Smole, U., Gour, N., Phelan, J., Hofer, G., Kohler, C., Kratzer, B., Tauber, P. A., Xiao, X., Yao, N., Dvorak, J., Caraballo, L., Puerta, L., Rosskopf, S., Chakir, J., Malle, E., Lane, A. P., Pickl, W. F., Lajoie, S. & Wills-Karp, M. Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity. Nat Immunol 21, 756-765, doi:10.1038/s41590-020-0698-1 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32572240.

Smole, U., Kratzer, B. & Pickl, W. F. Soluble pattern recognition molecules: Guardians and regulators of homeostasis at airway mucosal surfaces. Eur J Immunol 50, 624-642, doi:10.1002/eji.201847811 (2020).Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32246830.

Stockl, J. B., Schmid, N., Flenkenthaler, F., Drummer, C., Behr, R., Mayerhofer, A., Arnold, G. J. & Frohlich, T. Proteomic Insights into Senescence of Testicular Peritubular Cells from a Nonhuman Primate Model. Cells 9, doi:10.3390/cells9112498 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/33213088.

Thian, M., Hoeger, B., Kamnev, A., Poyer, F., Kostel Bal, S., Caldera, M., Jimenez-Heredia, R., Huemer, J., Pickl, W. F., Gross, M., Ehl, S., Lucas, C. L., Menche, J., Hutter, C., Attarbaschi, A., Dupre, L. & Boztug, K. Germline biallelic PIK3CG mutations in a multifaceted immunodeficiency with immune dysregulation. Haematologica 105, e488, doi:10.3324/haematol.2019.231399 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/33054089.

Tobias, J., Battin, C., De Sousa Linhares, A., Lebens, M., Baier, K., Ambroz, K., Drinic, M., Hogler, S., Inic-Kanada, A., Garner-Spitzer, E., Preusser, M., Kenner, L., Kundi, M., Zielinski, C. C., Steinberger, P. & Wiedermann, U. A New Strategy Toward B Cell-Based Cancer Vaccines by Active Immunization With Mimotopes of Immune Checkpoint Inhibitors. Front Immunol 11, 895, doi:10.3389/fimmu.2020.00895 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32528470.

Tulaeva, I., Kratzer, B., Campana, R., Curin, M., van Hage, M., Karsonova, A., Riabova, K., Karaulov, A., Khaitov, M., Pickl, W. F. & Valenta, R. Preventive Allergen-Specific Vaccination Against Allergy: Mission Possible? Front Immunol 11, 1368, doi:10.3389/fimmu.2020.01368 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32733455.

Villazala-Merino, S., Rodriguez-Dominguez, A., Stanek, V., Campion, N. J., Gattinger, P., Hofer, G., Froeschl, R., Fae, I., Lupinek, C., Vrtala, S., Breiteneder, H., Keller, W., Perkmann, T., Nakamura, R., Pickl, W. F., Valenta, R., Eckl-Dorna, J. & Niederberger, V. Allergen-specific IgE levels and the ability of IgE-allergen complexes to cross-link determine the extent of CD23-mediated T-cell activation. J Allergy Clin Immunol 145, 958-967 e955, doi:10.1016/j.jaci.2019.11.019 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31775017.

Zajc, C. U., Dobersberger, M., Schaffner, I., Mlynek, G., Puhringer, D., Salzer, B., Djinovic-Carugo, K., Steinberger, P., De Sousa Linhares, A., Yang, N. J., Obinger, C., Holter, W., Traxlmayr, M. W. & Lehner, M. A conformation-specific ON-switch for controlling CAR T cells with an orally available drug. Proc Natl Acad Sci U S A 117, 14926-14935, doi:10.1073/pnas.1911154117 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32554495.

Zimmermann-Klemd, A. M., Reinhardt, J. K., Morath, A., Schamel, W. W., Steinberger, P., Leitner, J., Huber, R., Hamburger, M. & Grundemann, C. Immunosuppressive Activity of Artemisia argyi Extract and Isolated Compounds. Front Pharmacol 11, 402, doi:10.3389/fphar.2020.00402 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32322200.

Affandi, A. J., Grabowska, J., Olesek, K., Lopez Venegas, M., Barbaria, A., Rodriguez, E., Mulder, P. P. G., Pijffers, H. J., Ambrosini, M., Kalay, H., O'Toole, T., Zwart, E. S., Kazemier, G., Nazmi, K., Bikker, F. J., Stockl, J., van den Eertwegh, A. J. M., de Gruijl, T. D., Storm, G., van Kooyk, Y. & den Haan, J. M. M. Selective tumor antigen vaccine delivery to human CD169(+) antigen-presenting cells using ganglioside-liposomes. Proc Natl Acad Sci U S A 117, 27528-27539, doi:10.1073/pnas.2006186117 (2020).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/33067394.