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2019

  1. Zentrum für Pathophysiologie, Infektiologie und Immunologie
  2. Unsere Abteilungen
  3. Institut für Immunologie
  4. Wissenschaft & Forschung/Forschungsabteilungen/Arbeitsgruppen
  5. Publikationen
  6. 2019

Publications 2019

Abdelaziz, M. O., Ossmann, S., Kaufmann, A. M., Leitner, J., Steinberger, P., Willimsky, G., Raftery, M. J. & Schonrich, G. Development of a Human Cytomegalovirus (HCMV)-Based Therapeutic Cancer Vaccine Uncovers a Previously Unsuspected Viral Block of MHC Class I Antigen Presentation. Front Immunol 10, 1776, doi:10.3389/fimmu.2019.01776 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31417555
 

Andersen, L., Gulich, A. F., Alteneder, M., Preglej, T., Orola, M. J., Dhele, N., Stolz, V., Schebesta, A., Hamminger, P., Hladik, A., Floess, S., Krausgruber, T., Faux, T., Andrabi, S. B. A., Huehn, J., Knapp, S., Sparwasser, T., Bock, C., Laiho, A., Elo, L. L., Rasool, O., Lahesmaa, R., Sakaguchi, S. & Ellmeier, W. The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3(+) Regulatory T Cells. Cell Rep 29, 4447-4459 e4446, doi:10.1016/j.celrep.2019.11.089 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31875552 
 

Bagnjuk, K., Stockl, J. B., Frohlich, T., Arnold, G. J., Behr, R., Berg, U., Berg, D., Kunz, L., Bishop, C., Xu, J. & Mayerhofer, A. Necroptosis in primate luteolysis: a role for ceramide. Cell Death Discov 5, 67, doi:10.1038/s41420-019-0149-7 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30774995
 

Battin, C., De Sousa Linhares, A., Paster, W., Isenman, D. E., Wahrmann, M., Leitner, J., Zlabinger, G. J., Steinberger, P. & Hofer, J. Neuropilin-1 Acts as a Receptor for Complement Split Products. Front Immunol 10, 2209, doi:10.3389/fimmu.2019.02209 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31572401


Colomar-Carando, N., Meseguer, A., Company-Garrido, I., Jutz, S., Herrera-Fernandez, V., Olvera, A., Kiefer, K., Brander, C., Steinberger, P. & Vicente, R. Zip6 Transporter Is an Essential Component of the Lymphocyte Activation Machinery. J Immunol 202, 441-450, doi:10.4049/jimmunol.1800689 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30552163


Conde, C. D., Petronczki, O. Y., Baris, S., Willmann, K. L., Girardi, E., Salzer, E., Weitzer, S., Ardy, R. C., Krolo, A., Ijspeert, H., Kiykim, A., Karakoc-Aydiner, E., Forster-Waldl, E., Kager, L., Pickl, W. F., Superti-Furga, G., Martinez, J., Loizou, J. I., Ozen, A., van der Burg, M. & Boztug, K. Polymerase delta deficiency causes syndromic immunodeficiency with replicative stress. J Clin Invest 129, 4194-4206, doi:10.1172/JCI128903 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31449058


Cossarizza, A., Chang, H. D., Radbruch, A., Acs, A., Adam, D., Adam-Klages, S., Agace, W. W., Aghaeepour, N., Akdis, M., Allez, M., Almeida, L. N., Alvisi, G., Anderson, G., Andra, I., Annunziato, F., Anselmo, A., Bacher, P., Baldari, C. T., Bari, S., Barnaba, V., Barros-Martins, J., Battistini, L., Bauer, W., Baumgart, S., Baumgarth, N., Baumjohann, D., Baying, B., Bebawy, M., Becher, B., Beisker, W., Benes, V., Beyaert, R., Blanco, A., Boardman, D. A., Bogdan, C., Borger, J. G., Borsellino, G., Boulais, P. E., Bradford, J. A., Brenner, D., Brinkman, R. R., Brooks, A. E. S., Busch, D. H., Buscher, M., Bushnell, T. P., Calzetti, F., Cameron, G., Cammarata, I., Cao, X., Cardell, S. L., Casola, S., Cassatella, M. A., Cavani, A., Celada, A., Chatenoud, L., Chattopadhyay, P. K., Chow, S., Christakou, E., Cicin-Sain, L., Clerici, M., Colombo, F. S., Cook, L., Cooke, A., Cooper, A. M., Corbett, A. J., Cosma, A., Cosmi, L., Coulie, P. G., Cumano, A., Cvetkovic, L., Dang, V. D., Dang-Heine, C., Davey, M. S., Davies, D., De Biasi, S., Del Zotto, G., Dela Cruz, G. V., Delacher, M., Della Bella, S., Dellabona, P., Deniz, G., Dessing, M., Di Santo, J. P., Diefenbach, A., Dieli, F., Dolf, A., Dorner, T., Dress, R. J., Dudziak, D., Dustin, M., Dutertre, C. A., Ebner, F., Eckle, S. B. G., Edinger, M., Eede, P., Ehrhardt, G. R. A., Eich, M., Engel, P., Engelhardt, B., Erdei, A., Esser, C., Everts, B., Evrard, M., Falk, C. S., Fehniger, T. A., Felipo-Benavent, M., Ferry, H., Feuerer, M., Filby, A., Filkor, K., Fillatreau, S., Follo, M., Forster, I., Foster, J., Foulds, G. A., Frehse, B., Frenette, P. S., Frischbutter, S., Fritzsche, W., Galbraith, D. W., Gangaev, A., Garbi, N., Gaudilliere, B., Gazzinelli, R. T., Geginat, J., Gerner, W., Gherardin, N. A., Ghoreschi, K., Gibellini, L., Ginhoux, F., Goda, K., Godfrey, D. I., Goettlinger, C., Gonzalez-Navajas, J. M., Goodyear, C. S., Gori, A., Grogan, J. L., Grummitt, D., Grutzkau, A., Haftmann, C., Hahn, J., Hammad, H., Hammerling, G., Hansmann, L., Hansson, G., Harpur, C. M., Hartmann, S., Hauser, A., Hauser, A. E., Haviland, D. L., Hedley, D., Hernandez, D. C., Herrera, G., Herrmann, M., Hess, C., Hofer, T., Hoffmann, P., Hogquist, K., Holland, T., Hollt, T., Holmdahl, R., Hombrink, P., Houston, J. P., Hoyer, B. F., Huang, B., Huang, F. P., Huber, J. E., Huehn, J., Hundemer, M., Hunter, C. A., Hwang, W. Y. K., Iannone, A., Ingelfinger, F., Ivison, S. M., Jack, H. M., Jani, P. K., Javega, B., Jonjic, S., Kaiser, T., Kalina, T., Kamradt, T., Kaufmann, S. H. E., Keller, B., Ketelaars, S. L. C., Khalilnezhad, A., Khan, S., Kisielow, J., Klenerman, P., Knopf, J., Koay, H. F., Kobow, K., Kolls, J. K., Kong, W. T., Kopf, M., Korn, T., Kriegsmann, K., Kristyanto, H., Kroneis, T., Krueger, A., Kuhne, J., Kukat, C., Kunkel, D., Kunze-Schumacher, H., Kurosaki, T., Kurts, C., Kvistborg, P., Kwok, I., Landry, J., Lantz, O., Lanuti, P., LaRosa, F., Lehuen, A., LeibundGut-Landmann, S., Leipold, M. D., Leung, L. Y. T., Levings, M. K., Lino, A. C., Liotta, F., Litwin, V., Liu, Y., Ljunggren, H. G., Lohoff, M., Lombardi, G., Lopez, L., Lopez-Botet, M., Lovett-Racke, A. E., Lubberts, E., Luche, H., Ludewig, B., Lugli, E., Lunemann, S., Maecker, H. T., Maggi, L., Maguire, O., Mair, F., Mair, K. H., Mantovani, A., Manz, R. A., Marshall, A. J., Martinez-Romero, A., Martrus, G., Marventano, I., Maslinski, W., Matarese, G., Mattioli, A. V., Maueroder, C., Mazzoni, A., McCluskey, J., McGrath, M., McGuire, H. M., McInnes, I. B., Mei, H. E., Melchers, F., Melzer, S., Mielenz, D., Miller, S. D., Mills, K. H. G., Minderman, H., Mjosberg, J., Moore, J., Moran, B., Moretta, L., Mosmann, T. R., Muller, S., Multhoff, G., Munoz, L. E., Munz, C., Nakayama, T., Nasi, M., Neumann, K., Ng, L. G., Niedobitek, A., Nourshargh, S., Nunez, G., O'Connor, J. E., Ochel, A., Oja, A., Ordonez, D., Orfao, A., Orlowski-Oliver, E., Ouyang, W., Oxenius, A., Palankar, R., Panse, I., Pattanapanyasat, K., Paulsen, M., Pavlinic, D., Penter, L., Peterson, P., Peth, C., Petriz, J., Piancone, F., Pickl, W. F., Piconese, S., Pinti, M., Pockley, A. G., Podolska, M. J., Poon, Z., Pracht, K., Prinz, I., Pucillo, C. E. M., Quataert, S. A., Quatrini, L., Quinn, K. M., Radbruch, H., Radstake, T., Rahmig, S., Rahn, H. P., Rajwa, B., Ravichandran, G., Raz, Y., Rebhahn, J. A., Recktenwald, D., Reimer, D., Reis e Sousa, C., Remmerswaal, E. B. M., Richter, L., Rico, L. G., Riddell, A., Rieger, A. M., Robinson, J. P., Romagnani, C., Rubartelli, A., Ruland, J., Saalmuller, A., Saeys, Y., Saito, T., Sakaguchi, S., Sala-de-Oyanguren, F., Samstag, Y., Sanderson, S., Sandrock, I., Santoni, A., Sanz, R. B., Saresella, M., Sautes-Fridman, C., Sawitzki, B., Schadt, L., Scheffold, A., Scherer, H. U., Schiemann, M., Schildberg, F. A., Schimisky, E., Schlitzer, A., Schlosser, J., Schmid, S., Schmitt, S., Schober, K., Schraivogel, D., Schuh, W., Schuler, T., Schulte, R., Schulz, A. R., Schulz, S. R., Scotta, C., Scott-Algara, D., Sester, D. P., Shankey, T. V., Silva-Santos, B., Simon, A. K., Sitnik, K. M., Sozzani, S., Speiser, D. E., Spidlen, J., Stahlberg, A., Stall, A. M., Stanley, N., Stark, R., Stehle, C., Steinmetz, T., Stockinger, H., Takahama, Y., Takeda, K., Tan, L., Tarnok, A., Tiegs, G., Toldi, G., Tornack, J., Traggiai, E., Trebak, M., Tree, T. I. M., Trotter, J., Trowsdale, J., Tsoumakidou, M., Ulrich, H., Urbanczyk, S., van de Veen, W., van den Broek, M., van der Pol, E., Van Gassen, S., Van Isterdael, G., van Lier, R. A. W., Veldhoen, M., Vento-Asturias, S., Vieira, P., Voehringer, D., Volk, H. D., von Borstel, A., von Volkmann, K., Waisman, A., Walker, R. V., Wallace, P. K., Wang, S. A., Wang, X. M., Ward, M. D., Ward-Hartstonge, K. A., Warnatz, K., Warnes, G., Warth, S., Waskow, C., Watson, J. V., Watzl, C., Wegener, L., Weisenburger, T., Wiedemann, A., Wienands, J., Wilharm, A., Wilkinson, R. J., Willimsky, G., Wing, J. B., Winkelmann, R., Winkler, T. H., Wirz, O. F., Wong, A., Wurst, P., Yang, J. H. M., Yang, J., Yazdanbakhsh, M., Yu, L., Yue, A., Zhang, H., Zhao, Y., Ziegler, S. M., Zielinski, C., Zimmermann, J. & Zychlinsky, A. Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol 49, 1457-1973, doi:10.1002/eji.201970107 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31633216


De Sousa Linhares, A., Battin, C., Jutz, S., Leitner, J., Hafner, C., Tobias, J., Wiedermann, U., Kundi, M., Zlabinger, G. J., Grabmeier-Pfistershammer, K. & Steinberger, P. Therapeutic PD-L1 antibodies are more effective than PD-1 antibodies in blocking PD-1/PD-L1 signaling. Sci Rep 9, 11472, doi:10.1038/s41598-019-47910-1 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31391510 


Ellmeier, W. & Seiser, C. Author Correction: Histone deacetylase function in CD4(+) T cells. Nat Rev Immunol 19, 266, doi:10.1038/s41577-019-0153-4 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30862885


Forsthuber, A., Lipp, K., Andersen, L., Ebersberger, S., Grana, C., Ellmeier, W., Petzelbauer, P., Lichtenberger, B. M. & Loewe, R. CXCL5 as Regulator of Neutrophil Function in Cutaneous Melanoma. J Invest Dermatol 139, 186-194, doi:10.1016/j.jid.2018.07.006 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30009831


Griss, J., Bauer, W., Wagner, C., Simon, M., Chen, M., Grabmeier-Pfistershammer, K., Maurer-Granofszky, M., Roka, F., Penz, T., Bock, C., Zhang, G., Herlyn, M., Glatz, K., Laubli, H., Mertz, K. D., Petzelbauer, P., Wiesner, T., Hartl, M., Pickl, W. F., Somasundaram, R., Steinberger, P. & Wagner, S. N. B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma. Nat Commun 10, 4186, doi:10.1038/s41467-019-12160-2 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31519915


Gulich, A. F., Preglej, T., Hamminger, P., Alteneder, M., Tizian, C., Orola, M. J., Muroi, S., Taniuchi, I., Ellmeier, W. & Sakaguchi, S. Differential Requirement of Cd8 Enhancers E8I and E8VI in Cytotoxic Lineage T Cells and in Intestinal Intraepithelial Lymphocytes. Front Immunol 10, 409, doi:10.3389/fimmu.2019.00409 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30915074


Humeniuk, P., Geiselhart, S., Battin, C., Webb, T., Steinberger, P., Paster, W. & Hoffmann-Sommergruber, K. Generation of a Jurkat-based fluorescent reporter cell line to evaluate lipid antigen interaction with the human iNKT cell receptor. Sci Rep 9, 7426, doi:10.1038/s41598-019-43529-4 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31092850


Humeniuk, P., Geiselhart, S., Battin, C., Webb, T., Steinberger, P., Paster, W. & Hoffmann-Sommergruber, K. Publisher Correction: Generation of a Jurkat-based fluorescent reporter cell line to evaluate lipid antigen interaction with the human iNKT cell receptor. Sci Rep 9, 16382, doi:10.1038/s41598-019-52827-w (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31690814


Kratzer, B., Kohler, C., Hofer, S., Smole, U., Trapin, D., Iturri, J., Pum, D., Kienzl, P., Elbe-Burger, A., Gattinger, P., Mittermann, I., Linhart, B., Gadermaier, G., Jahn-Schmid, B., Neunkirchner, A., Valenta, R. & Pickl, W. F. Prevention of allergy by virus-like nanoparticles (VNP) delivering shielded versions of major allergens in a humanized murine allergy model. Allergy 74, 246-260, doi:10.1111/all.13573 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30035810


Lawitschka, A., Gueclue, E. D., Januszko, A., Kormoczi, U., Rottal, A., Fritsch, G., Bauer, D., Peters, C., Greinix, H. T., Pickl, W. F. & Kuzmina, Z. National Institutes of Health-Defined Chronic Graft-vs.-Host Disease in Pediatric Hematopoietic Stem Cell Transplantation Patients Correlates With Parameters of Long-Term Immune Reconstitution. Front Immunol 10, 1879, doi:10.3389/fimmu.2019.01879 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31507582


Mayer, K. A., Stockl, J., Zlabinger, G. J. & Gualdoni, G. A. Hijacking the Supplies: Metabolism as a Novel Facet of Virus-Host Interaction. Front Immunol 10, 1533, doi:10.3389/fimmu.2019.01533 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31333664


Mir Seyed Nazari, P., Marosi, C., Moik, F., Riedl, J., Ozer, O., Berghoff, A. S., Preusser, M., Hainfellner, J. A., Pabinger, I., Zlabinger, G. J. & Ay, C. Low Systemic Levels of Chemokine C-C Motif Ligand 3 (CCL3) are Associated with a High Risk of Venous Thromboembolism in Patients with Glioma. Cancers (Basel) 11, doi:10.3390/cancers11122020 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31847343


Orola, M. J., Tizian, C., Zhu, C., Andersen, L., Gulich, A. F., Alteneder, M., Stojakovic, T., Wiedermann, U., Trauner, M., Ellmeier, W. & Sakaguchi, S. The zinc-finger transcription factor MAZR regulates iNKT cell subset differentiation. Cell Mol Life Sci 76, 4391-4404, doi:10.1007/s00018-019-03119-z (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31065747


Polak, D., Samadi, N., Vizzardelli, C., Sanchez Acosta, G., Rosskopf, S., Steinberger, P., Jahn-Schmid, B. & Bohle, B. Neutrophils promote T-cell-mediated inflammation in allergy. J Allergy Clin Immunol 143, 1923-1925 e1923, doi:10.1016/j.jaci.2018.11.035 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30578884


Polak, D., Hafner, C., Briza, P., Kitzmuller, C., Elbe-Burger, A., Samadi, N., Gschwandtner, M., Pfutzner, W., Zlabinger, G. J., Jahn-Schmid, B. & Bohle, B. A novel role for neutrophils in IgE-mediated allergy: Evidence for antigen presentation in late-phase reactions. J Allergy Clin Immunol 143, 1143-1152 e1144, doi:10.1016/j.jaci.2018.06.005 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29920351


Rosskopf, S., Leitner, J., Zlabinger, G. J. & Steinberger, P. CTLA-4 antibody ipilimumab negatively affects CD4(+) T-cell responses in vitro. Cancer Immunol Immunother 68, 1359-1368, doi:10.1007/s00262-019-02369-x (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31332464


Rydzek, J., Nerreter, T., Peng, H., Jutz, S., Leitner, J., Steinberger, P., Einsele, H., Rader, C. & Hudecek, M. Chimeric Antigen Receptor Library Screening Using a Novel NF-kappaB/NFAT Reporter Cell Platform. Mol Ther 27, 287-299, doi:10.1016/j.ymthe.2018.11.015 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30573301


Samadi, N., Polak, D., Kitzmuller, C., Steinberger, P., Zlabinger, G. J., Jahn-Schmid, B. & Bohle, B. T-cell-derived cytokines enhance the antigen-presenting capacity of human neutrophils. Eur J Immunol 49, 1441-1443, doi:10.1002/eji.201848057 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31332790


Schmetterer, K. G., Goldhahn, K., Ziegler, L. S., Gerner, M. C., Schmidt, R. L. J., Themanns, M., Zebedin-Brandl, E., Trapin, D., Leitner, J., Pickl, W. F., Steinberger, P., Schwarzinger, I. & Marculescu, R. Overexpression of PDE4A Acts as Checkpoint Inhibitor Against cAMP-Mediated Immunosuppression in vitro. Front Immunol 10, 1790, doi:10.3389/fimmu.2019.01790 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31417563


Schmid, N., Flenkenthaler, F., Stockl, J. B., Dietrich, K. G., Kohn, F. M., Schwarzer, J. U., Kunz, L., Luckner, M., Wanner, G., Arnold, G. J., Frohlich, T. & Mayerhofer, A. Insights into replicative senescence of human testicular peritubular cells. Sci Rep 9, 15052, doi:10.1038/s41598-019-51380-w (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31636313


Serwas, N. K., Hoeger, B., Ardy, R. C., Stulz, S. V., Sui, Z., Memaran, N., Meeths, M., Krolo, A., Yuce Petronczki, O., Pfajfer, L., Hou, T. Z., Halliday, N., Santos-Valente, E., Kalinichenko, A., Kennedy, A., Mace, E. M., Mukherjee, M., Tesi, B., Schrempf, A., Pickl, W. F., Loizou, J. I., Kain, R., Bidmon-Fliegenschnee, B., Schickel, J. N., Glauzy, S., Huemer, J., Garncarz, W., Salzer, E., Pierides, I., Bilic, I., Thiel, J., Priftakis, P., Banerjee, P. P., Forster-Waldl, E., Medgyesi, D., Huber, W. D., Orange, J. S., Meffre, E., Sansom, D. M., Bryceson, Y. T., Altman, A. & Boztug, K. Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis. Nat Commun 10, 3106, doi:10.1038/s41467-019-10812-x (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31308374


Serwas, N. K., Hoeger, B., Ardy, R. C., Stulz, S. V., Sui, Z., Memaran, N., Meeths, M., Krolo, A., Petronczki, O. Y., Pfajfer, L., Hou, T. Z., Halliday, N., Santos-Valente, E., Kalinichenko, A., Kennedy, A., Mace, E. M., Mukherjee, M., Tesi, B., Schrempf, A., Pickl, W. F., Loizou, J. I., Kain, R., Bidmon-Fliegenschnee, B., Schickel, J. N., Glauzy, S., Huemer, J., Garncarz, W., Salzer, E., Pierides, I., Bilic, I., Thiel, J., Priftakis, P., Banerjee, P. P., Forster-Waldl, E., Medgyesi, D., Huber, W. D., Orange, J. S., Meffre, E., Sansom, D. M., Bryceson, Y. T., Altman, A. & Boztug, K. Publisher Correction: Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis. Nat Commun 10, 4555, doi:10.1038/s41467-019-12454-5 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31578334


van Dinther, D., Lopez Venegas, M., Veninga, H., Olesek, K., Hoogterp, L., Revet, M., Ambrosini, M., Kalay, H., Stockl, J., van Kooyk, Y. & den Haan, J. M. M. Activation of CD8(+) T Cell Responses after Melanoma Antigen Targeting to CD169(+) Antigen Presenting Cells in Mice and Humans. Cancers (Basel) 11, doi:10.3390/cancers11020183 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30764534


Zabel, M., Tauber, P. A. & Pickl, W. F. The making and function of CAR cells. Immunol Lett 212, 53-69, doi:10.1016/j.imlet.2019.06.002 (2019).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31181279