Institut für Pathophysiologie und Allergieforschung

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Unter „Pathophysiologie“ versteht man, wie der menschliche Körper unter krankhaften Veränderungen abweichend funktioniert. Unsere Forschungsschwerpunke umfassen zelluläre und molekulare Pathophysiologie, Immunpathologie, Infektiologie, komparative Immunologie, medizinische Biotechnologie sowie Krebs- und Allergieforschung.

Univ.-Prof.in Dipl.-Ing.in Dr.in Barbara Bohle

Institutsleiterin

Tel.: +43 (0)1 40400-51140
E-Mail: barbara.bohle@meduniwien.ac.at

Katharina Vlasaty

Institutsreferentin

Tel.: +43 (0)1 40400-51190
Fax: +43 (0)1 40400-61880
E-Mail: katharina.vlasaty@meduniwien.ac.at

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Forschung Aktuell

Systems Biology in Bone Research

The 2024 Nobel Prize in Physiology or Medicine honors Victor Ambros and Gary Ruvkun for the discovery of microRNA (miRNA) and its role in post-transcriptional gene regulation. Research article of Anastasia Meshcheryakova et al, published just recently, brings attention to the RNA-binding proteins (RBPs), which regulates the biogenesis of miRNAs, in bone cells. The article is entitled “RNA-binding proteins as novel effectors in osteoblasts and osteoclasts: a systems biology approach to dissect the transcriptional landscape”. The systems biology-based integrative analysis in bone research field is still not yet exploiting to the extent as in other areas. With our manuscript, we would like to bring attention of the international bone society, including researches and medical specialists, to the comprehensive approach for biomarker discovery and identification of novel molecular networks for therapeutic interventions in bone-related disorders. This research project is collaboration between the research groups of Diana Mechtcheriakova and Peter Pietschmann.

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