Publications associated with the projects are listed here.
- Lines KE, Gluck AK, Thongjuea S, Bountra C, Thakker RV, Gorvin CM. The bromodomain inhibitor JQ1+ reduces calcium-sensing receptor activity in pituitary cell lines. J Mol Endocrinol. 2021 Jul 26;67(3):83-94. doi: 10.1530/JME-21-0030. PMID: 34223822; PMCID: PMC8345903.
- Sastre A, Valentino K, Hannan FM, Lines KE, Gluck AK, Stevenson M, Ryalls M, Gorrigan RJ, Pullen D, Buck J, Sankaranarayanan S, Allgrove J, Thakker RV, Gevers EF. PTH Infusion for Seizures in Autosomal Dominant Hypocalcemia Type 1. N Engl J Med. 2021 Jul 8;385(2):189-191. doi: 10.1056/NEJMc2034981. PMID: 34233101; PMCID: PMC7614858.
- Schepelmann M, Kupper N, Sladczyk M, Mansfield B, Manhardt T, Piatek K, Iamartino L, Riccardi D, Kariuki BM, Bassetto M, Kallay E. Stereo-Specific Modulation of the Extracellular Calcium-Sensing Receptor in Colon Cancer Cells. Int J Mol Sci. 2021 Sep 19;22(18):10124. doi: 10.3390/ijms221810124. PMID: 34576291; PMCID: PMC8464956.
- Romagnoli C, Sharma P, Zonefrati R, Palmini G, Lucattelli E, Ward DT, Ellinger I, Innocenti M, Brandi ML. Study of the Expression and Function of Calcium-Sensing Receptor in Human Skeletal Muscle. Int J Mol Sci. 2021 Jul 6;22(14):7282. doi: 10.3390/ijms22147282. PMID: 34298895; PMCID: PMC8304165.
- Hannan FM, Gorvin CM, Babinsky VN, Olesen MK, Stewart M, Wells S, Cox RD, Nemeth EF, Thakker RV. Calcilytic NPSP795 Increases Plasma Calcium and PTH in an Autosomal Dominant Hypocalcemia Type 1 Mouse Model. JBMR Plus. 2020 Sep 7;4(10):e10402. doi: 10.1002/jbm4.10402. PMID: 33103030; PMCID: PMC7574706.
- Iamartino L, Elajnaf T, Gall K, David J, Manhardt T, Heffeter P, Grusch M, Derdak S, Baumgartner-Parzer S, Schepelmann M, Kallay E. Effects of pharmacological calcimimetics on colorectal cancer cells over-expressing the human calcium-sensing receptor. Biochim Biophys Acta Mol Cell Res. 2020 Dec;1867(12):118836. doi: 10.1016/j.bbamcr.2020.118836. Epub 2020 Aug 27. PMID: 32861746.
- Elajnaf T, Iamartino L, Mesteri I, Müller C, Bassetto M, Manhardt T, Baumgartner-Parzer S, Kallay E, Schepelmann M. Nutritional and Pharmacological Targeting of the Calcium-Sensing Receptor Influences Chemically Induced Colitis in Mice. Nutrients. 2019 Dec 16;11(12):3072. doi: 10.3390/nu11123072. PMID: 31888253; PMCID: PMC6950720.
- Gorvin CM, Stokes VJ, Boon H, Cranston T, Glück AK, Bahl S, Homfray T, Aung T, Shine B, Lines KE, Hannan FM, Thakker RV. Activating Mutations of the G-protein Subunit α 11 Interdomain Interface Cause Autosomal Dominant Hypocalcemia Type 2. J Clin Endocrinol Metab. 2020 Mar 1;105(3):952–63. doi: 10.1210/clinem/dgz251. PMID: 31820785; PMCID: PMC7048683.
- Romagnoli C, Zonefrati R, Sharma P, Innocenti M, Cianferotti L, Brandi ML. Characterization of Skeletal Muscle Endocrine Control in an In Vitro Model of Myogenesis. Calcif Tissue Int. 2020 Jul;107(1):18-30. doi: 10.1007/s00223-020-00678-3. Epub 2020 Feb 27. PMID: 32107602; PMCID: PMC7271047.
- Dharmaraj P, Gorvin CM, Soni A, Nelhans ND, Olesen MK, Boon H, Cranston T, Thakker RV, Hannan FM. Neonatal Hypocalcemic Seizures in Offspring of a Mother With Familial Hypocalciuric Hypercalcemia Type 1 (FHH1). J Clin Endocrinol Metab. 2020 May 1;105(5):1393–400. doi: 10.1210/clinem/dgaa111. PMID: 32150253; PMCID: PMC7096312.
- Das S, Clézardin P, Kamel S, Brazier M, Mentaverri R. The CaSR in Pathogenesis of Breast Cancer: A New Target for Early Stage Bone Metastases. Front Oncol. 2020 Feb 5;10:69. doi: 10.3389/fonc.2020.00069. PMID: 32117726; PMCID: PMC7013091.
- Boisen IM, Mos I, Lerche-Black EM, Juul A, Bräuner-Osborne H, Blomberg Jensen M. Heterozygous Mutation (Q459R) in the Calcium-Sensing Receptor Gene Causes Familial Hypocalciuric Hypercalcemia 1 (FHH1). J Clin Endocrinol Metab. 2020 Apr 1;105(4):dgz205. doi: 10.1210/clinem/dgz205. PMID: 32160303.
- Elajnaf T, Iamartino L, Mesteri I, Müller C, Bassetto M, Manhardt T, Baumgartner-Parzer S, Kallay E, Schepelmann M. Nutritional and Pharmacological Targeting of the Calcium-Sensing Receptor Influences Chemically Induced Colitis in Mice. Nutrients. 2019 Dec 16;11(12):3072. doi: 10.3390/nu11123072. PMID: 31888253; PMCID: PMC6950720.
- Centeno PP, Herberger A, Mun HC, Tu C, Nemeth EF, Chang W, Conigrave AD, Ward DT. Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion. Nat Commun. 2019 Oct 16;10(1):4693. doi: 10.1038/s41467-019-12399-9. PMID: 31619668; PMCID: PMC6795806.
- Chavez-Abiega S, Goedhart J, Bruggeman FJ. Physical biology of GPCR signalling dynamics inferred from fluorescence spectroscopy and imaging. Curr Opin Struct Biol. 2019 Apr;55:204-211. doi: 10.1016/j.sbi.2019.05.007. Epub 2019 Jul 15. PMID: 31319372.
- Kumar N, ... , Mahbod A, Schaefer G, Ellinger I, Ecker R, Smedby O, Wang C, et al. A Multi-Organ Nucleus Segmentation Challenge. IEEE Trans Med Imaging. 2020 May;39(5):1380-1391. doi: 10.1109/TMI.2019.2947628. Epub 2019 Oct 23. PMID: 31647422.
- Mahbod, A., Schaefer, G., Ellinger, I., Ecker, R., Smedby, Ö., Wang, C. (2019). A Two-Stage U-Net Algorithm for Segmentation of Nuclei in H&E-Stained Tissues. In: Reyes-Aldasoro, C., Janowczyk, A., Veta, M., Bankhead, P., Sirinukunwattana, K. (eds) Digital Pathology. ECDP 2019. Lecture Notes in Computer Science(), vol 11435. Springer, Cham. https://doi.org/10.1007/978-3-030-23937-4_9
- Lo Giudice M, Mihalik B, Turi Z, Dinnyés A, Kobolák J. Calcilytic NPS 2143 Reduces Amyloid Secretion and Increases sAβPPα Release from PSEN1 Mutant iPSC-Derived Neurons. J Alzheimers Dis. 2019;72(3):885-899. doi: 10.3233/JAD-190602. PMID: 31640098; PMCID: PMC6918902.
- García M, Rodríguez-Hernández CJ, Mateo-Lozano S, Pérez-Jaume S, Gonçalves-Alves E, Lavarino C, Mora J, de Torres C. Parathyroid hormone-like hormone plays a dual role in neuroblastoma depending on PTH1R expression. Mol Oncol. 2019 Sep;13(9):1959-1975. doi: 10.1002/1878-0261.12542. Epub 2019 Jul 19. PMID: 31293052; PMCID: PMC6717746.
- Mahbod A, Schaefer G, Ellinger I, Ecker R, Pitiot A, Wang C. Fusing fine-tuned deep features for skin lesion classification. Comput Med Imaging Graph. 2019 Jan;71:19-29. doi: 10.1016/j.compmedimag.2018.10.007. Epub 2018 Nov 3. PMID: 30458354.
- Iamartino L, Elajnaf T, Kallay E, Schepelmann M. Calcium-sensing receptor in colorectal inflammation and cancer: Current insights and future perspectives. World J Gastroenterol. 2018 Sep 28;24(36):4119-4131. doi: 10.3748/wjg.v24.i36.4119. PMID: 30271078; PMCID: PMC6158479.
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Collection of papers on the role of the physiology and patophysiology of the CaSR. https://www.frontiersin.org/research-topics/4063/physiology-and-pathophysiology-of-the-extracellular-calcium-sensing-receptor. Among the authors: Aggarwal A., Brown E., Conigrave A., Da Torres C., Ellinger I., Kallay E.
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Mahbod, A., Ellinger, I., Ecker, R., Smedby, Ö., Wang, C. (2018). Breast Cancer Histological Image Classification Using Fine-Tuned Deep Network Fusion. In: Campilho, A., Karray, F., ter Haar Romeny, B. (eds) Image Analysis and Recognition. ICIAR 2018. Lecture Notes in Computer Science(), vol 10882. Springer, Cham. https://doi.org/10.1007/978-3-319-93000-8_85
- Ochalek A, Mihalik B, Avci HX, Chandrasekaran A, Téglási A, Bock I, Giudice ML, Táncos Z, Molnár K, László L, Nielsen JE, Holst B, Freude K, Hyttel P, Kobolák J, Dinnyés A. Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation. Alzheimers Res Ther. 2017 Dec 1;9(1):90. doi: 10.1186/s13195-017-0317-z. PMID: 29191219; PMCID: PMC5709977.
- Hannan FM, Olesen MK, Thakker RV. Calcimimetic and calcilytic therapies for inherited disorders of the calcium-sensing receptor signalling pathway. Br J Pharmacol. 2018 Nov;175(21):4083-4094. doi: 10.1111/bph.14086. Epub 2017 Dec 11. PMID: 29127708; PMCID: PMC6177618.
- Mahbod A, Schaefer G, Wang C, Ecker R, Ellinger I. Skin Lesion Classification Using Hybrid Deep Neural Networks. 2019. https://arxiv.org/abs/1702.08434
- Aggarwal A, Kállay E. Cross Talk between the Calcium-Sensing Receptor and the Vitamin D System in Prevention of Cancer. Front Physiol. 2016 Oct 18;7:451. doi: 10.3389/fphys.2016.00451. PMID: 27803671; PMCID: PMC5067519.
- Ellinger I. The Calcium-Sensing Receptor and the Reproductive System. Front Physiol. 2016 Aug 30;7:371. doi: 10.3389/fphys.2016.00371. PMID: 27625611; PMCID: PMC5003915.