Aktuelle Publikationen
Autoantibody development is associated with clinical severity of COVID-19: A cohort study.
Brinkmann M, Traby L, Kussmann M, Weiss-Tessbach M, Buchtele N, Staudinger T, Gaidoschik E, Perkmann T, Haslacher H, Ratzinger F, Pickl WF, El-Gedawi K, Feichter M, Gelpi E, Höftberger R, Quehenberger P, Marculescu R, Mrak D, Kastrati K, Lechner-Radner H, Sieghart D, Aletaha D, Winkler S, Bonelli M, Göschl L. Clin Immunol. 2025 May;274:110471. doi: 10.1016/j.clim.2025.110471. Epub 2025 Mar 3. PMID: 40044018
Disappearance of antiphospholipid antibodies after anti-CD19 chimeric antigen receptor T-cell therapy of B-cell lymphoma in a patient with systemic lupus erythematosus and antiphospholipid syndrome.
Friedberg E, Wohlfarth P, Schiefer AI, Skrabs C, Pickl WF, Worel N, Staber P, Jäger U, Ay C. J Thromb Haemost. 2025 Jan;23(1):262-266. doi: 10.1016/j.jtha.2024.09.024. Epub 2024 Oct 10. PMID: 39393780 Free article.
Differential decline of SARS-CoV-2-specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID-19.
Kratzer B, Gattinger P, Trapin D, Ettel P, Körmöczi U, Rottal A, Stieger RB, Sehgal ANA, Feichter M, Borochova K, Tulaeva I, Grabmeier-Pfistershammer K, Tauber PA, Perkmann T, Fae I, Wenda S, Kundi M, Fischer GF, Valenta R, Pickl WF. Allergy. 2024 Sep;79(9):2482-2501. doi: 10.1111/all.16210. Epub 2024 Jul 14. PMID: 39003594
Flow Cytometry-Based Measurement of Antibodies Specific for Cell Surface-Expressed Folded SARS-CoV-2 Receptor-Binding Domains.
Sehgal ANA, Safran J, Kratzer B, Gattinger P, Stieger RB, Musiejovsky L, Trapin D, Ettel P, Körmöczi U, Rottal A, Borochova K, Dorofeeva Y, Tulaeva I, Weber M, Grabmeier-Pfistershammer K, Perkmann T, Wiedermann U, Valenta R, Pickl WF. Vaccines (Basel). 2024 Apr 1;12(4):377. doi: 10.3390/vaccines12040377. PMID: 38675759 Free PMC article.
Lower magnitude and faster waning of antibody responses to SARS-CoV-2 vaccination in anti-TNF-α-treated IBD patients are linked to lack of activation and expansion of cTfh1 cells and impaired B memory cell formation.
Garner-Spitzer E, Wagner A, Gudipati V, Schoetta AM, Orola-Taus M, Kundi M, Kunert R, Mayrhofer P, Huppa JB, Stockinger H, Carsetti R, Gattinger P, Valenta R, Kratzer B, Sehgal ANA, Pickl WF, Reinisch W, Novacek G, Wiedermann U. EBioMedicine. 2023 Oct;96:104788. doi: 10.1016/j.ebiom.2023.104788. Epub 2023 Sep 4. PMID: 37672867 Free PMC article.
Evans syndrome caused by a deleterious mutation affecting the adaptor protein SASH3.
Novak W, Berner J, Svaton M, Jimenez-Heredia R, Segarra-Roca A, Frohne A, Guiliani S, Rouhani D, Eder SK, Rottal A, Trapin D, Scheuchenstuhl A, Pickl WF, Simonitsch-Klupp I, Kager L, Boztug K. Br J Haematol. 2023 Nov;203(4):678-683. doi: 10.1111/bjh.19061. Epub 2023 Aug 30. PMID: 37646304
Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.
Block J, Rashkova C, Castanon I, Zoghi S, Platon J, Ardy RC, Fujiwara M, Chaves B, Schoppmeyer R, van der Made CI, Jimenez Heredia R, Harms FL, Alavi S, Alsina L, Sanchez Moreno P, Ávila Polo R, Cabrera-Pérez R, Kostel Bal S, Pfajfer L, Ransmayr B, Mautner AK, Kondo R, Tinnacher A, Caldera M, Schuster M, Domínguez Conde C, Platzer R, Salzer E, Boyer T, Brunner HG, Nooitgedagt-Frons JE, Iglesias E, Deyà-Martinez A, Camacho-Lovillo M, Menche J, Bock C, Huppa JB, Pickl WF, Distel M, Yoder JA, Traver D, Engelhardt KR, Linden T, Kager L, Hannich JT, Hoischen A, Hambleton S, Illsinger S, Da Costa L, Kutsche K, Chavoshzadeh Z, van Buul JD, Antón J, Calzada-Hernández J, Neth O, Viaud J, Nishikimi A, Dupré L, Boztug K. N Engl J Med. 2023 Aug 10;389(6):527-539. doi: 10.1056/NEJMoa2210054. Epub 2023 Jun 21. PMID: 37342957
Glycopeptide Antibiotics Impair Neutrophil Effector Functions.
Ettel P, Sehgal ANA, Harrison N, Pickl WF, Grabmeier-Pfistershammer K. Int Arch Allergy Immunol. 2023;184(9):932-948. doi: 10.1159/000530865. Epub 2023 Jun 15. PMID: 37321197 Free article.
Mycobacterium avium Complex Infections: Detailed Phenotypic and Functional Immunological Work-Up Is Required despite Genetic Analyses.
Kratzer B, Grabmeier-Pfistershammer K, Trapin D, Körmöczi U, Rottal A, Feichter M, Waidhofer-Söllner P, Smogavec M, Laccone F, Hauser M, Winkler S, Pickl WF, Lechner AM. Int Arch Allergy Immunol. 2023;184(9):914-931. doi: 10.1159/000530844. Epub 2023 Jun 6. PMID: 37279717 Free article.
Lessons for the Clinical Nephrologist: Nephrotic syndrome associated with refractory Giardia duodenalis infection in a patient with acquired B cell depletion.
Eder M, Pimenov L, Böhmig GA, Kornek B, Göschl L, Bond G, Vossen MG, Pickl WF, Breuer M, Görzer I, Kozakowski N, Laferl H, Winkler S. J Nephrol. 2023 May;36(4):1197-1201. doi: 10.1007/s40620-023-01601-3. Epub 2023 Mar 17. PMID: 36930433 Free PMC article. No abstract available.
The frequency of differentiated CD3+CD27-CD28- T cells predicts response to CART cell therapy in diffuse large B-cell lymphoma.
Worel N, Grabmeier-Pfistershammer K, Kratzer B, Schlager M, Tanzmann A, Rottal A, Körmöczi U, Porpaczy E, Staber PB, Skrabs C, Herkner H, Gudipati V, Huppa JB, Salzer B, Lehner M, Saxenhuber N, Friedberg E, Wohlfarth P, Hopfinger G, Rabitsch W, Simonitsch-Klupp I, Jäger U, Pickl WF. Front Immunol. 2023 Jan 9;13:1004703. doi: 10.3389/fimmu.2022.1004703. eCollection 2022. PMID: 36700229 Free PMC article.
A homozygous AP3D1 missense variant in patients with sensorineural hearing loss as the leading manifestation.
Frohne A, Koenighofer M, Cetin H, Nieratschker M, Liu DT, Laccone F, Neesen J, Nemec SF, Schwarz-Nemec U, Schoefer C, Avraham KB, Frei K, Grabmeier-Pfistershammer K, Kratzer B, Schmetterer K, Pickl WF, Parzefall T. Hum Genet. 2023 Aug;142(8):1077-1089. doi: 10.1007/s00439-022-02506-0. Epub 2022 Nov 29. PMID: 36445457 Free PMC article.
Reactogenicity and immunogenicity of the second COVID-19 vaccination in patients with inborn errors of immunity or mannan-binding lectin deficiency.
Göschl L, Mrak D, Grabmeier-Pfistershammer K, Stiasny K, Haslacher H, Schneider L, Deimel T, Kartnig F, Tobudic S, Aletaha D, Burgmann H, Bonelli M, Pickl WF, Förster-Waldl E, Scheinecker C, Vossen MG. Front Immunol. 2022 Sep 14;13:974987. doi: 10.3389/fimmu.2022.974987. eCollection 2022. PMID: 36189225 Free PMC article.
Combined assessment of S- and N-specific IL-2 and IL-13 secretion and CD69 neo-expression for discrimination of post-infection and post-vaccination cellular SARS-CoV-2-specific immune response.
Kratzer B, Schlax LC, Gattinger P, Waidhofer-Söllner P, Trapin D, Tauber PA, Sehgal ANA, Körmöczi U, Rottal A, Feichter M, Oberhofer T, Grabmeier-Pfistershammer K, Borochova K, Dorofeeva Y, Tulaeva I, Weber M, Mühl B, Kropfmüller A, Negrin B, Kundi M, Valenta R, Pickl WF. Allergy. 2022 Nov;77(11):3408-3425. doi: 10.1111/all.15406. Epub 2022 Jul 19. PMID: 35690994 Free PMC article.
SARS-CoV-2-mRNA Booster Vaccination Reverses Non-Responsiveness and Early Antibody Waning in Immunocompromised Patients - A Phase Four Study Comparing Immune Responses in Patients With Solid Cancers, Multiple Myeloma and Inflammatory Bowel Disease.
Wagner A, Garner-Spitzer E, Schötta AM, Orola M, Wessely A, Zwazl I, Ohradanova-Repic A, Weseslindtner L, Tajti G, Gebetsberger L, Kratzer B, Tomosel E, Kutschera M, Tobudic S, Pickl WF, Kundi M, Stockinger H, Novacek G, Reinisch W, Zielinski C, Wiedermann U. Front Immunol. 2022 May 12;13:889138. doi: 10.3389/fimmu.2022.889138. eCollection 2022. PMID: 35634285 Free PMC article. Clinical Trial.
Vaccine based on folded receptor binding domain-PreS fusion protein with potential to induce sterilizing immunity to SARS-CoV-2 variants.
Gattinger P, Kratzer B, Tulaeva I, Niespodziana K, Ohradanova-Repic A, Gebetsberger L, Borochova K, Garner-Spitzer E, Trapin D, Hofer G, Keller W, Baumgartner I, Tancevski I, Khaitov M, Karaulov A, Stockinger H, Wiedermann U, Pickl WF, Valenta R. Allergy. 2022 Aug;77(8):2431-2445. doi: 10.1111/all.15305. Epub 2022 Apr 15. PMID: 35357709 Free PMC article.
Lack of Induction of RBD-Specific Neutralizing Antibodies despite Repeated Heterologous SARS-CoV-2 Vaccination Leading to Seroconversion and Establishment of T Cell-Specific Memory in a Patient in Remission of Multiple Myeloma.
Kratzer B, Trapin D, Gattinger P, Oberhofer T, Sehgal ANA, Waidhofer-Söllner P, Rottal A, Körmöczi U, Grabmeier-Pfistershammer K, Kopetzky GH, Tischer F, Valenta R, Pickl WF. Vaccines (Basel). 2022 Feb 27;10(3):374. doi: 10.3390/vaccines10030374. PMID: 35335006 Free PMC article.
Characterization of the antibody response to SARS-CoV-2 in a mildly affected pediatric population.
Kopanja S, Gattinger P, Schmidthaler K, Sieber J, Niepodziana K, Schlederer T, Weseslindtner L, Stiasny K, Götzinger F, Pickl WF, Frischer T, Valenta R, Szépfalusi Z. Pediatr Allergy Immunol. 2022 Feb;33(2):e13737. doi: 10.1111/pai.13737. PMID: 35212039 Free PMC article.
Omicron: A SARS-CoV-2 variant of real concern.
Gattinger P, Tulaeva I, Borochova K, Kratzer B, Trapin D, Kropfmüller A, Pickl WF, Valenta R. Allergy. 2022 May;77(5):1616-1620. doi: 10.1111/all.15264. Epub 2022 Feb 28. PMID: 35188670 Free PMC article. No abstract available.
Value of Autoantibody Expression During Long-Term Follow-Up in Paediatric ALL Patients After Allogeneic Haematopoietic Stem Cell Transplantation.
Lawitschka A, Ronceray L, Bauer D, Rittenschober M, Zubarovskaya N, Geyeregger R, Pickl WF, Kuzmina Z. Front Pediatr. 2021 Dec 21;9:788360. doi: 10.3389/fped.2021.788360. eCollection 2021. PMID: 34993166 Free PMC article.